Table 1.

Aberrant expression of biomarkers in human bronchoalveolar adenocarcinomas

GeneCbln1Cldn2Dlk1Fgl1Foxa3Gjb1HNF4αShhSlc2a3Tmem27TtrErd2Ucp1
Normal (ΔCt)16.274.426.795.265.207.904.369.203.375.484.843.38
26.346.066.536.485.877.964.348.891.237.685.224.0810.74
35.024.855.278.134.337.182.817.981.177.625.124.2212.99
45.855.467.375.764.838.103.698.591.428.094.292.117.83
57.406.418.397.766.698.875.12112.86106.033.678.25
Average normal ΔCt6.185.446.876.685.388.004.069.142.017.785.103.499.95
Patient (ΔCt)12.550.823.884.921.153.81−0.0125.895.562.490.940.74
24.562.304.798.572.795.502.167.294.727.213.663.4214.79
36.99−0.356.544.23.863.743.898.996.855.383.282.85
46.433.286.991.324.887.684.129.716.617.475.515.729.42
50.830.143.131.26−0.332.08−1.434.745.887.17−0.693.8410.52
60.860.452.345.34−0.053.29−1.265.076.027.73−0.897.47
72.001.003.000.321.003.640.006.006.005.090.183.65
84.812.264.772.582.946.522.518.415.136.963.264.79
94.55−2.284.88−1.193.064.931.418.095.263.371.394.09
105.955.891.800.065.887.894.468.594.184.295.461.40
Average patient ΔCt3.951.354.212.742.524.911.597.285.625.722.213.7911.19
ΔΔCT2.234.092.663.942.863.092.481.86−3.612.072.88−0.3−1.23
Fold change4.6816.986.3115.397.288.555.573.630.084.197.410.810.43
  • NOTE: Genes that were up-regulated or down-regulated in Stat3C bitransgenic mice (Supplementary Tables S1 and S2) were examined in the lungs of 5 normal human subjects and in bronchoalveolar adenocarcinoma of 10 human patients. Real-time PCR was normalized by GAPDH mRNA expression. Fold changes were determined by 2(ΔΔCT), in which ΔΔCT = ΔCt (normal) − ΔCt (patients). Normal: lung tissues from human subjects without bronchoalveolar adenocarcinoma. Patient: lung tissues from human subjects with bronchoalveolar adenocarcinoma.