Table 2.

Inhibition of MDM2 and MDMX-p53 binding by peptides in ELISA

Peptides (compound)SequencesIC50 for MDM2 (μmol/L)IC50 for MDMX (μmol/L)
p53pepQETFSDLWKLLP3.0027.50
12/1MPRFMDYWEGLN0.151.25
Nutlin0.60No inhibition
pDILTFEHYWAQLTS0.010.10
p3ALTAEHYAAQATSNo inhibitionNo inhibition