Table 2.

Expression levels of ATC-specific genes in human ATC cell lines

Expression level (fold change ATC cells versus normal thyrocytes) *
Cell lineP53 statusTOP2ACENPAPRC1CCNB2CDCA8NEK2TTKPLK1CDC20CENPF
AROR273H , 1.62.46.13.94.36.886.524
SW1736Null §8.813.57.710.412.9182581NDND
NPAG266V , 4.814.48.196.311.716.546.688
BHT101I251T 2.13.51.82.22.53.616.710.8NDND
KAT-4R273H , 6.75.95.59.79.2141327.1108
C643R248Q 2.73.92.546.55.925.58.3NDND
CAL62A161D NDNDNDNDNDND25.725.788
FRONull 3.83.93.13.54.59.132.514.3NDND
  • NOTE: Values are the average results of three independent determinations.

    Abbreviation: ND, not done.

  • * Quantitative RT-PCR analysis done as indicated in the legend to Fig. 1A. For each gene, the expression level in a given ATC cell line was obtained by comparing its fluorescence threshold with the average fluorescence thresholds of two normal thyroid cell populations (P53N and S11N).

  • Ref. 22.

  • Ref. 34.

  • § Ref. 24.