Table 1.

Apc mutations in MDF and tumors induced by DMH in rat

LesionHistologyCrypts/focusNucleotide positionAmino acid positionNucleotide changeAmino acid change
TumorsAdenocarcinoma3,1861,045GAA → TAAGlu → Stop
Adenoma3,1941,047TGG → TGATrp → Stop
Adenoma3,1941,047TGG → TGATrp → Stop
Adenocarcinoma3,1941,047TGG → TGATrp → Stop
Adenoma3,2461,065CAA → TAAGln → Stop
Adenocarcinoma3,3871,112CGA → TGAArg → Stop
Adenoma3,8101,253CAA → TAAGln → Stop
MDF803,0841,011CAT → TATHis → Tyr
153,1941,047TGG → TGATrp → Stop
93,1941,047TGG → TGATrp → Stop
113,2311,060CAA → TAAGln → Stop
63,8221,257CAG → TAGGln → Stop
74,4441,464GGT → GATGly → Asp