Table 1.

Genes up regulated in parous rats

Fold-change G1P1 versus G0P0
Gene nameSymbolGene IDFunctionCategoryLewisWFF344CopMedian
Immunoglobulin heavy chainIgha314487ImmunoglobulinImmune39.425.412.46.918.9
Casein betaCsn229173Milk proteinDifferentiation8.05.21.61.53.4
IgM light chain287965ImmunoglobulinImmune2.53.82.01.62.2
Insulin-like growth factor binding protein 5Igfbp525285Igf1-bindingGrowth factor/ECM2.41.41.12.71.9
Casein gammaCsng114595Milk proteinDifferentiation3.11.91.80.91.9
Lipopolysaccharide binding proteinLbp29469AntibacterialImmune2.11.31.02.01.7
Matrix metalloproteinase 12Mmp12117033ProteolysisECM/Immune2.61.41.61.31.5
Carbonic anhydrase 2Ca254231Carbon metabolismMetabolism1.51.51.51.11.5
Fatty acid synthaseFasn50671Fatty acid biosynthesisMetabolism/Differentation2.01.61.30.91.5
Cytochrome P450, family 4, subfamily b,1Cyp4b124307Monooxygenase activityMetabolism1.61.51.41.21.4
Transforming growth factor, beta 3Tgfb325717Cell growth/proliferationTgf-β1.51.30.91.41.4
Thioesterase domain containing 1Thedc164669Fatty acid biosynthesisMetabolism/Differentation1.91.20.81.51.3
Malic enzyme 1Me124552Pyruvate synthesisMetabolism1.31.41.41.11.3
Phosphodiesterase 4BPde4b24626cAMP phoshodiesteraseSignal transduction1.31.40.81.41.3
Polymeric immunoglobulin receptorPigr25046TrancytosisImmune1.71.41.21.11.3
Kruppel-like factor 9Klf9117560Transcription FactorSignal transduction1.31.41.21.11.3
Matrix metalloproteinase 11Mmp1125481ProteolysisECM1.21.21.21.21.2
  • NOTE: Genes identified as up-regulated by at least 1.2-fold in three out of four rat strains as a result of parity are reported from highest to lowest median fold-change. Gene names and symbols are reported based on the Rat Genome Database, and Gene ID according to Entrez Gene. Gene functions and categories are based upon GeneOntology.

    Abbreviations: WF, Wistar-Furth; F344, Fischer 344; Cop, Copenhagen.