Genes down-regulated in parous rats
| Fold-change G0P0 versus G1P1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene name | Symbol | Gene ID | Function | Category | Lewis | WF | F344 | Cop | Median |
| Periostin | Postn | 361945 | Cell adhesion | ECM | 1.9 | 2.1 | 1.6 | 2.2 | 2.0 |
| Amphiregulin | Areg | 29183 | Epidermal growth factor receptor ligand | Growth factor | 3.5 | 2.1 | 1.9 | 1.9 | 2.0 |
| Cellular retinoic acid binding protein I | Crabp1 | 25061 | Retinoic acid receptor signaling | Signal transduction | 1.8 | 2.1 | 1.3 | 1.5 | 1.7 |
| Glycosylation dependent cell adhesion molecule 1 | Glycam1 | 25258 | Selectin ligand | Differentiation | 0.5 | 2.2 | 1.3 | 1.7 | 1.5 |
| Secreted acidic cysteine rich glycoprotein | Sparc | 24791 | ECM Formation | ECM | 1.9 | 1.3 | 1.1 | 1.7 | 1.5 |
| Lumican | Lum | 81682 | Proteoglycan | ECM | 1.3 | 1.5 | 1.5 | 1.4 | 1.5 |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 | Hmgcs2 | 24450 | Cholesterol/ketone body biosynthesis | Metabolism | 2.9 | 1.3 | 1.6 | 1.0 | 1.5 |
| Fibronectin 1 | Fn1 | 25661 | Integrin signaling | ECM | 1.4 | 1.3 | 1.3 | 1.6 | 1.4 |
| Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 | Cited1 | 64466 | Transcription factor | Signal transduction | 1.4 | 1.9 | 1.3 | 1.3 | 1.4 |
| Ectonucleotide pyrophosphatase/phosphodiesterase 2 | Enpp2 | 84050 | Lysophospholipase | Cell motility | 1.7 | 1.4 | 0.8 | 1.3 | 1.4 |
| Insulin-like growth factor 1 | Igf1 | 24482 | Cell proliferation/survival | Growth factor | 1.7 | 1.2 | 1.1 | 1.5 | 1.3 |
| Sushi-repeat-containing protein | Sprx | 64316 | 1.3 | 1.3 | 1.1 | 1.5 | 1.3 | ||
| Lectin, galactose binding, soluble 1 | Lgals1 | 56646 | Integrin signaling | ECM | 1.5 | 1.2 | 0.8 | 1.4 | 1.3 |
| A kinase (PRKA) anchor protein (gravin) 12 | Akap12 | 83425 | Scaffolding protein | Signal transduction | 1.2 | 1.6 | 1.2 | 1.3 | 1.3 |
| Lectin, galactose binding, soluble 7 | Lgals7 | 29518 | Galactose binding | 1.1 | 1.8 | 1.4 | 1.2 | 1.3 | |
| Tropomyosin 1, alpha | Tpm1 | 24851 | Actin binding | 1.1 | 1.3 | 1.3 | 1.3 | 1.3 | |
| Activity and neurotransmitter induced early gene protein 4 | Ania4 | 360341 | CAM kinase | Kinase | 1.5 | 1.2 | 1.0 | 1.3 | 1.3 |
| Cytosolic cysteine dioxygenase 1 | Cdo1 | 81718 | Cysteine metabolism | Metabolism | 1.5 | 1.2 | 0.8 | 1.3 | 1.3 |
| Carbonic anhydrase 3 | Ca3 | 54232 | Carbon metabolism | Metabolism | 1.8 | 1.2 | 0.8 | 1.3 | 1.2 |
| CD74 antigen | Cd74 | 25599 | Immune | 1.2 | 1.2 | 1.3 | 1.3 | 1.2 | |
| Tubulin, alpha 1 | Tuba1 | 64158 | Microtubule component | Cell structure | 1.5 | 1.2 | 0.9 | 1.2 | 1.2 |
| Similar to RIKEN cDNA 6330406I15 | RGD1307396 | 360757 | 1.6 | 1.2 | 1.0 | 1.3 | 1.2 | ||
| Collagen, type 1, alpha 1 | Col1a1 | 29393 | ECM structural protein | ECM | 0.9 | 1.2 | 1.2 | 1.6 | 1.2 |
| Phosphoglycerate kinase 1 | Pgk1 | 24644 | Phosphoprotein glycolysis | Metabolism | 1.6 | 1.2 | 0.9 | 1.2 | 1.2 |
| Annexin A5 | Anxa5 | 25673 | Calcium ion binding | 1.6 | 1.2 | 0.8 | 1.2 | 1.2 | |
| Prohibitin | Phb | 25344 | Regulation of cell cycle | Signal transduction | 1.3 | 1.2 | 1.2 | 1.1 | 1.2 |
| Valosin-containing protein | Vcp | 116643 | Endoplasmic reticulum protein catabolism | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | |
| Tropomyosin 4 | Tpm4 | 24852 | Actin binding | 1.1 | 1.3 | 1.2 | 1.2 | 1.2 | |
| Tubulin, beta 5 | Tubb5 | 29214 | Microtubule component | Cell structure | 1.1 | 1.3 | 1.2 | 1.2 | 1.2 |
| MORF-related gene X | Morf412 | 317413 | 1.4 | 1.2 | 1.0 | 1.2 | 1.2 | ||
NOTE: Genes identified as down-regulated by at least 1.2-fold in three out of four rat strains as a result of parity are reported from highest to lowest median fold-change. Gene names and symbols are reported based on the Rat Genome Database, and Gene ID according to Entrez Gene. Gene functions and categories are based upon GeneOntology.
Abbreviations: WF, Wistar-Furth; F344, Fischer 344; Cop, Copenhagen.