Table 2.

Genes down-regulated in parous rats

Fold-change G0P0 versus G1P1
Gene nameSymbolGene IDFunctionCategoryLewisWFF344CopMedian
PeriostinPostn361945Cell adhesionECM1.92.11.62.22.0
AmphiregulinAreg29183Epidermal growth factor receptor ligandGrowth factor3.52.11.91.92.0
Cellular retinoic acid binding protein ICrabp125061Retinoic acid receptor signalingSignal transduction1.82.11.31.51.7
Glycosylation dependent cell adhesion molecule 1Glycam125258Selectin ligandDifferentiation0.52.21.31.71.5
Secreted acidic cysteine rich glycoproteinSparc24791ECM FormationECM1.91.31.11.71.5
LumicanLum81682ProteoglycanECM1.31.51.51.41.5
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2Hmgcs224450Cholesterol/ketone body biosynthesisMetabolism2.91.31.61.01.5
Fibronectin 1Fn125661Integrin signalingECM1.41.31.31.61.4
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1Cited164466Transcription factorSignal transduction1.41.91.31.31.4
Ectonucleotide pyrophosphatase/phosphodiesterase 2Enpp284050LysophospholipaseCell motility1.71.40.81.31.4
Insulin-like growth factor 1Igf124482Cell proliferation/survivalGrowth factor1.71.21.11.51.3
Sushi-repeat-containing proteinSprx643161.31.31.11.51.3
Lectin, galactose binding, soluble 1Lgals156646Integrin signalingECM1.51.20.81.41.3
A kinase (PRKA) anchor protein (gravin) 12Akap1283425Scaffolding proteinSignal transduction1.21.61.21.31.3
Lectin, galactose binding, soluble 7Lgals729518Galactose binding1.11.81.41.21.3
Tropomyosin 1, alphaTpm124851Actin binding1.11.31.31.31.3
Activity and neurotransmitter induced early gene protein 4Ania4360341CAM kinaseKinase1.51.21.01.31.3
Cytosolic cysteine dioxygenase 1Cdo181718Cysteine metabolismMetabolism1.51.20.81.31.3
Carbonic anhydrase 3Ca354232Carbon metabolismMetabolism1.81.20.81.31.2
CD74 antigenCd7425599Immune1.21.21.31.31.2
Tubulin, alpha 1Tuba164158Microtubule componentCell structure1.51.20.91.21.2
Similar to RIKEN cDNA 6330406I15RGD13073963607571.61.21.01.31.2
Collagen, type 1, alpha 1Col1a129393ECM structural proteinECM0.91.21.21.61.2
Phosphoglycerate kinase 1Pgk124644Phosphoprotein glycolysisMetabolism1.61.20.91.21.2
Annexin A5Anxa525673Calcium ion binding1.61.20.81.21.2
ProhibitinPhb25344Regulation of cell cycleSignal transduction1.31.21.21.11.2
Valosin-containing proteinVcp116643Endoplasmic reticulum protein catabolism1.21.21.21.21.2
Tropomyosin 4Tpm424852Actin binding1.11.31.21.21.2
Tubulin, beta 5Tubb529214Microtubule componentCell structure1.11.31.21.21.2
MORF-related gene XMorf4123174131.41.21.01.21.2
  • NOTE: Genes identified as down-regulated by at least 1.2-fold in three out of four rat strains as a result of parity are reported from highest to lowest median fold-change. Gene names and symbols are reported based on the Rat Genome Database, and Gene ID according to Entrez Gene. Gene functions and categories are based upon GeneOntology.

    Abbreviations: WF, Wistar-Furth; F344, Fischer 344; Cop, Copenhagen.