Table 2.

Summary of study findings (n = 45)

GroupNMDM2-SNP309 (non-WT)SNP309 and TP53 codon 72 polymorphismsTRF, mean (SD)
Child
    Affected carrier88 (100%)6 (75%)7.8 (0.46)
    Nonaffected carrier33 (100%)1 (33%)9.0 (0.26)
    WT159.1 (0.6)
Adult
    Affected carrier54 (80%)1 (20%)6.8 (0.45)
    Nonaffected carrier43 (75%)2 (50%)7.7 (0.72)
    WT108.6 (0.9)
  • NOTE: Subjects were designated as either children (age at sampling, <18 years) or adults (age at sampling, >18 years) and subsequently categorized as affected (has/had cancer) germ line mutant TP53 carriers, nonaffected mutant TP53 carriers, and WT TP53 carriers.

    Abbreviation: TRF, terminal restriction fragment assay. Telomere length is measured in kilobase.