Table 1.

Radiotracer uptake in viable and necrotic tumor, as well as in various organs, obtained from rats and mice bearing s.c. rat F98 and RG2 gliomas and human Gli36dEGFR and U87dEGFR gliomas

FDG (ROI/BG)FLT (ROI/BG)MET (ROI/BG)FDG (%ID/g)FLT (%ID/g)
Tumors
    F986.39 ± 3.30 (n = 9)4.02 ± 2.46 (n = 16)3.66 ± 1.25 (n = 9)1.17 ± 0.06 (n = 16)0.90 ± 0.34 (n = 8)
        Rim1.91 ± 0.49 (n = 2)0.30 ± 0.17 (n = 2)
        Necrosis0.63 ± 0.05 (n = 2)-0.12 ± 0.02 (n = 2)
    RG22.04 ± 0.22 (n = 5)
        Rim7.98 ± 2.02 (n = 3)2.59 ± 0.00 (n = 2)
        Necrosis0.81 ± 0.13 (n = 3)0.40 ± 0.07 (n = 2)
    U87dEGFR3.95 ± 1.75 (n = 3)2.21 ± 0.23 (n = 9)3.86 ± 0.45 (n = 2)0.27 ± 0.09 (n = 9)
    Gli36dEGFR2.79 ± 0.81 (n = 18)2.38 ± 0.40 (n = 3)2.62 ± 0.15 (n = 4)1.72 ± 1.11 (n = 6)
        Rim3.43 ± 0.13 (n = 2)4.17 ± 0.22 (n = 2)
        Necrosis1.16 ± 0.29 (n = 2)0.28 ± 0.50 (n = 2)
Organs
    Brain2.88 ± 1.27 (n = 11)0.30 ± 0.07 (n = 9)1.29 ± 0.46 (n = 2)1.24 ± 0.83 (n = 4)-0.22 ± 0.06 (n = 6)
    Kidney7.21 ± 6.87 (n = 7)9.97 ± 6.32 (n = 10)5.35 ± 1.57 (n = 3)2.90 ± 1.33 (n = 6)
    Bladder37.62 ± 28.55 (n = 10)20.73 ± 11.31 (n = 9)8.32 ± 2.75 (n = 3)10.56 ± 2.17 (n = 3)13.16 ± 9.40 (n = 6)
    Intestine8.10 ± 1.67 (n = 2)
    Heart3.29 ± 1.00 (n = 6)
    Liver12.01 ± 2.70 (n = 6)
    Salivary glands5.69 ± 1.77 (n = 2)
    Bone3.26 ± 0.30 (n = 2)
  • Abbreviations: ROI, region of interest; BG, background.