Table 1.

Effect of supplementation with IdB 1016 on lung metastasizing and on leukocyte reactive infiltrate in HER-2/neu transgenic female mice

ControlIdB 1016 (twice a week)IdB 1016 (daily)P
Lung metastases
    Mean no. of metastases3.332.003.33Not significant
    Mice with metastases (%)8360 *670.01
    Mean size of metastases (mm)2.11 *10.01
    Maximum size of metastases (mm)411Not significant
Leukocyte infiltrate
    Neutrophil1.2 ± 0.54.8 ± 1.80.008
    Macrophage48.3 ± 5.039.5 ± 21.4Not significant
    CD4+4.4 ± 0.78.5 ± 0.70.0008
    CD8+2.1 ± 0.67.2 ± 0.70.0001
  • * Difference with control mice was significant (P < 0.01).

  • Cell counts were determined at ×400 in 0.180 mm2/field. At least five fields/tissue were evaluated. Values are expressed as the mean ± SD.