Table 1.

Cancer cell lines used in this study with IC50 to dasatinib, sensitivity classification by IC50, and predicted sensitivity by the six-gene predictor

Cell lineIC50 (╬╝mol/L)Sensitivity classification based on IC50Sensitivity prediction by six-gene predictor
(A) Training set of breast cancer cell lines
MDA-MB-1570.0055Sensitive
MDA-MB-2310.0095Sensitive
HCC19540.0242Sensitive
HCC700.0337Sensitive
BT-200.1652Sensitive
HCC18060.2194Sensitive
HS578T0.6472Sensitive
HCC14192.5093Resistant
SK-BR-32.7534Resistant
AU-5655.2399Resistant
HCC386.6327Resistant
BT-4746.7375Resistant
MDA-MB-4687.1258Resistant
HCC14287.2926Resistant
MDA-MB-435S7.7800Resistant
H33968.1950Resistant
BT-5499.0576Resistant
ZR-75-309.2632Resistant
MCF7>9.524Resistant
MCF7/Her2>9.524Resistant
MDA-MB-436>9.524Resistant
ZR-75-1>9.524Resistant
MDA-MB-453>9.524Resistant
(B) Testing set of breast cancer cell lines
HCC11430.0235SensitiveSensitive
MBA-MB-4150.0394SensitiveResistant
HCC19370.0706SensitiveSensitive
HCC13950.0818SensitiveSensitive
UACC-8121.2158ResistantResistant
MDA-MB-3611.4383ResistantResistant
HCC11871.5793ResistantResistant
DU44752.6329ResistantResistant
HCC21575.4530ResistantResistant
HCC2025.5841ResistantResistant
HCC22188.6515ResistantResistant
HCC1500>8.926ResistantResistant
(C) Testing set of lung cancer cell lines
SK-LU-10.0137SensitiveSensitive
L29870.0371SensitiveSensitive
H2260.0583SensitiveSensitive
H8380.0724SensitiveSensitive
H6610.1231SensitiveSensitive
NCI-H5960.1238SensitiveSensitive
H4410.1411SensitiveSensitive
SK-MES-10.1512SensitiveSensitive
H5220.2151SensitiveResistant
SW12710.2424SensitiveSensitive
SW9000.5074SensitiveSensitive
H23471.0246ResistantResistant
H11551.0246ResistantResistant
H231.0246ResistantSensitive
A-427>1.025ResistantResistant
ChaGo-K-1>1.025ResistantSensitive
A549>1.025ResistantSensitive
Calu-6>1.025ResistantResistant
DMS114>1.025ResistantResistant
DMS53>1.025ResistantResistant
H157>1.025ResistantResistant
LX-1>1.025ResistantResistant
SHP-77>1.025ResistantResistant