Distribution of “high” and “low” expresser of ER, PR, HER2, and KRT5/17 between dasatinib-responder and nonresponder breast tumor groups predicted by the six-gene predictor
Gene | Expression level * | Predicted nonresponder (80) | Predicted responder (54) | χ2 test (P) |
---|---|---|---|---|
HER2 | H | 46 | 21 | 0.035 |
L | 34 | 33 | ||
ER | H | 47 | 20 | 0.014 |
L | 33 | 34 | ||
PR | H | 45 | 22 | 0.078 |
L | 35 | 32 | ||
KRT 5/17 | H | 28 | 31 | 0.010 |
L | 52 | 23 |
↵* The median expression level of a gene across the 134 tumors was used to define “high” (H) or “low” (L) expression. A tumor was designated as “L” if its expression was below the median level and designated as “H” if its expression was above the median.