Table 1.

Effect of RAD001 on tumor development in a mouse model of ovarian cancer

TreatmentNo. miceNo. mice with tumors (%)No. mice with advanced tumors (%)No. mice with early tumors (%)Tumor volume (mm3)Median time for tumor to reach 50 mm3 (d)Incidence of ascites formation (%)Tumor typeIncidence of ascites formation (%)
MedianMean
Placebo2929 (100)29 (100)0 (0)429.2551.59073.9Advanced73.90
Early tumor0
RAD0012928 (96.6)19 (67.9) *9 (32.1) *26.2 *91.4 *>12221.4 *Advanced31.6 *
Early tumor0
  • * Significantly different from placebo group (P < 0.01).