Table 2.

MicroRNAs as candidate tumor suppressors or oncogenes

MicroRNAsColonHematologicCNSStudies establishing function in primary tumors
Copies/cellFold decreaseCopies/cellFold decreaseCopies/cellFold decrease
Normal tissueTumor linesNormal tissueTumor linesNormal tissueTumor lines
(A) Candidate tumor suppressor microRNAs
hsa-miR-2141,838 *01,838
hsa-miR-42483516.6
hsa-miR-130a501 3514.3Down-regulated in colon cancer; Lu et al. ( 7)
hsa-miR-3782792113.3
hsa-miR-148a1,3922066.75
hsa-miR-15a2,6525524.8Antiapoptotic, targets BCL2, down-regulated in chronic lymphocyte leukemia; Calin et al. ( 9)
hsa-miR-422a5769.5
hsa-miR-283803012.6
hsa-miR-10a5114012.8
hsa-miR-196b147159.8
hsa-miR-27b1,0221178.7
hsa-miR-124b5,23315,233
hsa-miR-124a2,77902,779
hsa-miR-7N2981251.3
hsa-miR-1531881188
hsa-miR-77975.1155.4
hsa-miR-2191330133
hsa-miR-38383.6183.6
hsa-miR-12982182
hsa-miR-128b73073Up-regulated in colon, lung and pancreatic cancers; Volinia et al. ( 41)
hsa-miR-323358659.6
hsa-miR-128a49049
hsa-miR-346721.742.3
hsa-miR-33034034
hsa-miR-34080326.6
hsa-miR-34aN4771826.5
hsa-miR-1371,4956622.6
hsa-miR-13822022
hsa-miR-3219,09644820
hsa-miR-18719.3119.3
hsa-miR-338170918.8
hsa-miR-34a56318.6
hsa-miR-1499265217.7
hsa-miR-20353317.3Down-regulated in colon cancer; Lu et al. ( 7)
hsa-miR-3284802817
hsa-miR-42582613.6
hsa-miR-135a8807012.5
hsa-miR-154 *11011
hsa-miR-37054510.8
hsa-miR-981891810.5
hsa-miR-382181189.7
hsa-miR-1077088.75Up-regulated in colon, lung and pancreatic cancers; Volinia et al. ( 41)
hsa-miR-361228297.8
hsa-let-7g3,3134497.3
hsa-miR-1342947.25
hsa-miR-331399596.7
hsa-miR-17-3p1326.5B-Cell lymphoma; He ( 12)
hsa-miR-181c95156.3Down-regulated in glioblastomas; Ciafre et al. ( 18)
hsa-miR-30c5,5228766.3Down-regulated in glioblastomas; Ciafre et al. ( 18)
hsa-miR-21265115.9
hsa-let-7d365645.6
hsa-miR-1031,1242085.4
hsa-miR-2134285.2Down-regulated in colon cancer; Lu et al. ( 7)
hsa-miR-148b116235.1
hsa-miR-19444.98.85.1
hsa-miR-26b3,1626574.8
hsa-miR-181a1,9384104.7Down-regulated in glioblastomas; Ciafre et al. ( 18)
hsa-miR-19267144.5
hsa-miR-1911,0782464.4
hsa-miR-324-3p306744
hsa-miR-324-5p339834
hsa-let-7iN1,2733223.9
hsa-miR-30bN6231,5853.9
hsa-miR-3260173.5
hsa-miR-30b1,6504833.4
hsa-miR-30d3501083.2
hsa-miR-181b3,0559813.1
hsa-miR-345161572.8
hsa-miR-1973061192.5
hsa-miR-20N8293252.5
(B) Candidate oncogenic microRNAs
hsa-miR-10a0.8 *108136
hsa-miR-196a1 64.964.9
hsa-miR-196b136.5136.5
hsa-miR-10b81,86123.2Up-regulated in glioblastomas
hsa-miR-2180914,36117.7Up-regulated in glioblastomas, breast, colon, lung, pancreatic, prostate, and stomach cancers; Chan et al. ( 19)
  • NOTE: MicroRNAs that were either significantly down-regulated (potential tumor suppressor microRNAs; A) or significantly-up-regulated (potential oncogenic microRNAs; B) in only one of the hematological, colon, or CNS tumor–derived cell line clusters are shown. Each of the three clusters selected had multiple normal tissue controls (n > 3) to which they could be compared. The microRNAs listed showed expression levels in one set of tumor cell lines significantly different from that observed in the corresponding normal tissue. The RNA copy number in the cell lines as well as in normal tissue is listed for each microRNA. The microRNAs are listed in descending order of fold change from the expression level in the corresponding normal tissue.

  • * MicroRNAs that are in boldface show tissue-specific expression patterns, i.e., these microRNAs vary significantly among corresponding normal tissue comparisons.

  • MicroRNAs that are in italics are not tissue-specific, i.e., these microRNAs do not vary significantly among corresponding normal tissue comparisons.

  • MicroRNAs are down-regulated in either colon or hematologic cancer lines, but are up-regulated in CNS tumor lines compared with normal brain tissue and may act as potential oncogenes ( Table 2B).