Table 3.

Potential targets of microRNAs up-regulated in CNS tumors and CNS tumor–derived cell lines

Gene Name and symbol *Mean normalMean GlioblastomaPMicroRNAs predicted to target the listed gene
Visinin-like 1 (VSNL1)2.53−0.320.00040miR-196a
Sparc/osteonectin, cwcv and kazal-like domains proteoglycan1 (SPOCK1)2.29−0.290.00006miR_21
Reticulon 4 receptor (RTN4R)2.19−0.180.00001miR-10a, miR-10b
EGF-like repeats and discoidin I-like domains 3 (EDIL3)2.02−0.110.00644miR-21
Reticulon 4 receptor (RTN4R)2.01−0.110.00042miR-10a, miR-10b
ST6 beta-galactosamide alpha-2,6-sialyltranferase1 (ST6GAL1)1.850.440.00093miR-21
Reticulon 4 receptor (RTN4R)1.79−0.100.00044miR-10a, miR-10b
Mannan-binding lectin serine peptidase2 (MASP2)1.680.640.00176miR-10a, miR-10b
Fused toes homolog (mouse) FTS1.550.930.03596miR-196a, miR-196b
EGF-like repeats and discoidin I-like domains 3 EDIL31.38−0.200.00022miR-21
Zinc finger, MYND domain containing 11 ZMYND111.360.520.00892miR-10a
Tropomyosin 1 (alpha) TPM11.290.140.00540miR-21
Transcriptional adaptor 2 (ADA2 homolog, yeast)-like TADA2L1.170.400.00455miR-21
RUN and SH3 domain containing 2 RUSC21.07−0.040.00001miR-10a, miR-10b
Copine IV CPNE40.950.210.00131miR-196a, miR-196b
TBP-like 1 TBPL10.820.300.01409miR-196a, miR-196b
v-ski sarcoma viral oncogene homolog (avian) SKI0.67−0.040.02134miR-21
RB1CC1 || RB1-inducible coiled-coil 1 RB1CC10.36−0.240.00358miR-10b
Signal transducing adaptor molecule (SH3 domain and ITAM motif) 10.32−0.240.02060miR-196a
NPC1 (Niemann-Pick disease, type C1, gene)-like 1 NPC1L10.18−0.920.00133miR-196a
RB1CC1 || RB1-inducible coiled-coil 1 RB1CC10.17−0.340.00310miR-10b
Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) GOT10.08−1.600.00001miR-10b
Jumonji, AT rich interactive domain 2 JARID20.00−0.840.00914miR-10a, miR-10b
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) NHP2L1−0.05−0.660.01998miR-10a, miR-10b
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide ATP5B−0.74−1.370.02689miR-21
cAMP responsive element binding protein 3-like 1 CREB3L1−0.44−1.210.03011miR-196a, miR-196b
Tumor-associated calcium signal transducer 1 TACSTD1−3.35−4.380.00001miR-21