Table 4.

Association of genotypes on chromosome 8q24 with sporadic, familial, and aggressive PC

ComparisonMarkerGenotypeGenotype frequencyOR (95% CI) *P
PC CasesControls
Sporadic PC vs. controlsX/X0.8460.8501.00 (reference)
X/−80.1050.1021.04 (0.69–1.56)0.87
DG8S737X/−100.0410.0430.97 (0.52–1.81)0.91
−8/−80.0020.0060.34 (0.04–3.27)0.35
−8/−100.0060.00.92
−10/−100.00.0
C/C0.7800.8051.00 (reference)
rs1447295A/C0.2010.1851.12 (0.82–1.54)0.48
A/A0.0180.0101.88 (0.62–5.65)0.26
Familial PC vs. controlsX/X0.7670.8501.00 (reference)
X/−80.1620.1022.04 (1.22–3.42)0.007
DG8S737X/−100.0650.0431.91 (0.89–4.13)0.10
−8/−80.0070.0060.91 (0.07–11.03)0.94
−8/−100.00.0
−10/−100.00.0
C/C0.6810.8051.00 (reference)
rs1447295A/C0.3030.1852.05 (1.36–3.10)0.0007
A/A0.0160.0101.83 (0.40–8.44)0.44
Aggressive PC vs. controlsX/X0.7690.8501.00 (reference)
X/−80.1130.1021.23 (0.71–2.12)0.46
DG8S737X/−100.0970.0432.51 (1.30–4.84)0.006
−8/−80.0050.0060.97 (0.10–9.44)0.98
−8/−100.0110.00.95
−10/−100.0050.00.97
C/C0.6880.8051.00 (reference)
rs1447295A/C0.2800.1851.77 (1.19–2.62)0.005
A/A0.0320.0103.71 (1.11–12.37)0.03
  • * OR comparing subjects with the indicated genotype to subjects with genotype X/X, where X = all DG8S737 alleles other than −8 and −10.