Table 5.

Association of haplotypes on chromosome 8q24 with sporadic, familial, and aggressive PC

Haplotype *ControlsSporadic PCFamilial PCAggressive PC
Frequency (%)Frequency (%)Simulated PFrequency (%)Simulated PFrequency (%)Simulated P
GlobalHaplotypeGlobalHaplotypeGlobalHaplotype
DG8S737rs14472950.2670.0060.005
−12163C0.0200.0220.7820.0230.4150.0270.485
−10165A0.0150.0210.3130.0310.0190.0590.00005
−8167A0.0460.0460.9490.0820.0080.0670.138
−8167C0.0110.0120.8210.006
−6169A0.0300.0460.0950.0510.1150.0320.869
−6169C0.0520.0570.5620.0390.4210.0620.443
−4171C0.1660.1300.0360.1680.7160.1320.130
−2173C0.2210.1960.1400.1710.0810.2020.440
0175C0.0970.1040.7070.1020.9800.0940.863
2177C0.1170.1350.1810.0960.3060.1020.443
4179C0.0750.0840.5070.0920.1350.0720.869
6181C0.0590.0620.8030.0790.3050.0730.356
8183C0.0570.0600.8690.0430.3310.0480.494
10185C0.0100.0150.3090.0050.0130.755
  • * All haplotypes with frequencies <1% were collapsed into one group for the analysis but are not listed in the table. The most common haplotype was used as the baseline reference in the haplotype global test.