Table 2.

The genotypic association results between prostate cancer and the rs1447295 marker in African Americans and Caucasians stratified by age at diagnosis (≤65 and >65) in the BPC3

EthnicityMAF *Age at diagnosisGenotypeCases (%)Controls (%)OR 99% CI P§
CasesControlsLCLUCL
All (Phet = 0.036) 0.170.13≤65CC1,235 (69.1)1,675 (75.8)Ref.7.82 × 10−9
AC479 (26.8)490 (22.2)1.401.151.71
AA73 (4.1)44 (2.0)2.611.554.38
0.160.12>65CC3,457 (71.6)3,971 (77.3)Ref.4.09 × 10−7
AC1,221 (25.3)1,064 (20.7)1.271.121.44
AA149 (3.1)103 (2.0)1.491.052.09
African American0.400.31≤65CC64 (37.4)119 (46.5)Ref.0.011
(Phet = 0.037) AC77 (45.1)116 (45.3)1.260.732.18
AA30 (17.5)21 (8.2)2.631.146.05
0.320.31>65CC238 (47.1)187 (48.3)Ref.0.924
AC213 (42.2)162 (41.9)1.010.701.46
AA54 (10.7)38 (9.8)1.100.602.01
Caucasian, w/MEC0.150.11≤65CC1,171 (72.5)1,556 (79.7)Ref.6.12 × 10−7
(Phet = 0.164) AC402 (24.9)374 (19.1)1.421.151.76
AA43 (2.6)23 (1.2)2.501.274.93
0.140.11>65CC3,219 (74.5)3,784 (79.6)Ref.6.06 × 10−8
AC1,008 (23.3)902 (19.0)1.301.141.49
AA95 (2.2)65 (1.4)1.651.092.52
Caucasian, w/o MEC0.150.11≤65CC1,070 (72.0)1,410 (79.4)Ref.1.03 × 10−6
(Phet = 0.144) AC376 (25.3)343 (19.3)1.441.151.80
AA41 (2.7)22 (1.3)2.481.244.97
0.140.11>65CC2,972 (74.4)3,568 (79.6)Ref.2.29 × 10−7
AC936 (23.4)851 (19.0)1.311.141.50
AA87 (2.2)62 (1.4)1.611.042.48
  • NOTE: Age at diagnosis was missing for 37 Caucasians (23 cases and 14 controls). The Caucasian results are shown including and excluding the MEC samples.

  • * Minor allele frequency (A) for rs1447295.

  • All conditional logistic regression models were frequency adjusted for age in 5-y intervals, cohort, and country.

  • 99% CI; lower and upper confidence limits.

  • § The P value for association from a LRT with 2 df.

  • The P value for the LRT for heterogeneity across age with 1 df.