Table 1.

Comparison of C93, C75, and TOFA

DrugTargetFAS inhibition IC50 (μg/mL)Pathway inhibition IC50 (μg/mL)SKOV3 XTT LC50 (μg/mL)CPT-1 stimulationFAO stimulation SC150 (μg/mL)Maximum weight loss [% (i.p. dose)]
C93FAS305.5 ± 0.52.6 ± 0.3NoneNone1.4 (60 mg/kg)
C75FAS/CPT-11010.8 ± 2.711.0 ± 2.3300% at 20 μg/mL1.7 ± 2.015.0 (30 mg/kg)
TOFAACCNA0.20 ± 0.02442.4 ± 1.8NoneNone0 (60 mg/kg)
  • Abbreviations: FAO, fatty acid oxidation; SC150, stimulatory concentration 150; NA, not applicable.