Table 1.

Neuropathogenicity of wt poliovirus PV(M), dual-crePV, mono-crePV, and A133Gmono-crePV

VirusPLD50 (pfu) * in PVR transgenic micePLD50 (pfu) * in PVR transgenic A/J mice
wt PV1(M)101.8102.0
Dual-crePV>107.0>107.0
Mono-crePV>107.0>107.0
A133Gmono-crePV104.5104.8
  • * Defined as the amount of virus that causes paralysis or death in 50% of PVR transgenic mice or PVR transgenic A/J mice after i.c. inoculation.