Table 1.

Neuropathogenicity of wt poliovirus PV(M), dual-crePV, mono-crePV, and A₁₃₃Gmono-crePV

Virus	PLD₅₀ (pfu) * in PVR transgenic mice	PLD₅₀ (pfu) * in PVR transgenic A/J mice
wt PV1(M)	10^1.8	10^2.0
Dual-crePV	>10^7.0	>10^7.0
Mono-crePV	>10^7.0	>10^7.0
A₁₃₃Gmono-crePV	10^4.5	10^4.8

↵* Defined as the amount of virus that causes paralysis or death in 50% of PVR transgenic mice or PVR transgenic A/J mice after i.c. inoculation.