Table 2.

Several cancer-related genes showed higher amplification and deletion frequencies in cell lines than tumors of their respective histology

GeneChromosomeMbHistologyCell lines, n (%)Tumor, n (%)
AmplificationsMYC8128.7Breast5 of 22 (22.7)4 of 90 (4.4)
Ovary6 of 27 (22.2)7 of 76 (9.2)
Lung6 of 40 (15)0 of 51 (0)
Colon8 of 37 (21.6)11 of 223 (4.9)
RECQL48145.7Breast15 of 22 (68.1)10 of 90 (11.1)
Ovary8 of 27 (29.6)8 of 76 (10.5)
SS18L12061.4Breast6 of 22 (27.3)1 of 90 (1.1)
CCND11169.2Lung5 of 40 (12.5)0 of 51 (0)
FANCA1689.6Breast7 of 22 (31.8)0 of 90 (0)
CBFA2T31688.7Breast7 of 22 (31.8)0 of 90 (0)
ARNT1148.0Lung7 of 40 (17.5)0 of 51 (0)
AF1Q1148.2Lung7 of 40 (17.5)0 of 51 (0)
EXT18118.8Ovary6 of 27 (22.2)5 of 76 (6.6)
ERCC513101.2Colon6 of 37 (16.2)5 of 223 (2.2)
BRCA21330.7Colon8 of 37 (21.6)5 of 223 (2.2)
Homozygous deletionsCDKN2A922.0Lung7 of 40 (17.5)3 of 51 (5.9)
Melanoma5 of 42 (11.9)1 of 145 (0.7)
Pancreas3 of 24 (12.5)0 of 13 (0)
MLLT3920.3Melanoma4 of 42 (9.5)1 of 145 (0.7)
Pancreas3 of 24 (12.5)0 of 13 (0)