Table 1.

HIP1 expression in normal and neoplastic tissue samples

Tissue sample categoryPositiveNegativeFrequencyPLR *
Normal brain tissue (n = 75)21540.28
All brain tumors (n = 78 total, 54 glial)49290.63 2.2
    Glioma (n = 7)701.00 3.6
    Oligodendroglioma (n = 9)720.78 2.8
    GBM (n = 38)27110.71 2.5
        EGFR-positive GBM (n = 14)930.792.8
        PDGFβR-positive GBM (n = 6)601.003.6
        EGFR- or PDGFβR-positive GBM § (n = 17)1430.82 §2.9
        EGFR- and PDGFβR-negative GBM (n = 11)560.451.6
  • Abbreviation: GBM, glioblastoma multiforme.

  • * PLR (positive likelihood ratio) = sensitivity / (1 − specificity).

  • P ≤ 0.001, compared with HIP1 staining in normal brain tissue.

  • P ≤ 0.01, compared with HIP1 staining in normal brain tissue.

  • § P ≤ 0.05, compared with EGFR- and PDGFβR-negative glioblastoma multiforme.