Table 2.

In vivo tumorigenicity of CD44+CD117+ ovarian tumor cells

Tumor/cell typeCell doses and tumor formation and latency (d)Serial transplantation rate
1005001,0005,00010,000100,000500,000
T1 xenograft
    CD44+CD117+2/2 (77, 93)2/2 (65, 78)2/2 (62, 70)3/3
    CD44CD1170/20/20/21/2 (132)
T2 xenograft
    CD44+CD117+2/2 (52, 72)2/2 (59, 80)2/2 (43, 65)3/3
    CD44CD1170/20/20/22/2 (91, 103)
T3 primary
    CD44+CD117+2/2 (63, 75)2/2 (50, 74)2/2 (65, 89)3/3
    CD44CD1170/20/20/20/2
T4 spheroids
    CD44+CD117+1/2 (55)2/2 (42, 60)2/2 (60, 69)N/A
    CD44CD1170/20/20/20/2
T5 spheroids
    CD44+CD117+2/2 (50, 65)1/2 (52)2/2 (45, 62)N/A
    CD44CD1170/20/20/20/2
  • NOTE: All in vivo tumorigenicity experiments were done in the left flank of athymic mice by s.c. injection.

    Abbreviation: N/A, not applicable.