Table 1.

Top 10 pathways enriched in genes induced by the TCM-treated hMSCs for 30 d

PathwaysGenes induced in the MSC treated by TCM for 30 d
MAPK signaling pathway (P = 0.0001)BRAFDUSP6RAC1CACNG6TP53PPP3CBSTMN1DUSP14DUSP5JUND
JUNNFKB1PAK2IKBKBMKNK2CDC25BNFKB2RRAS2CASP1PDGFRB
PAK1TGFB1NRASATF4HSPA8MAP4K4FOSFGFR1RASA1FAS
MAP3K4HSPA9BCASP7CRKGADD45ADAXXMAPK1RPS6KA3
Focal adhesion (P = 0.0148)BRAFRAC1BIRC4PPP1CCTNCCOL6A3JUNCAPN2SPP1VASP
ITGA3PIK3R5PAK2COL6A1ITGB3BCL2COL5A3PPP1CATLN2CCND2
RRAS2PDGFRBPAK1PDGFCITGB7PXNNRASCOL6A2VEGFDIAPH1
GRLF1FYNCRKPAK3ITGA7LAMB1ITGA2ITGAVMAPK1IBSP
Cell cycle (P = 0.0148)MCM6PTTG1TP53CDKN1ACCNB1MAD2L2ANAPC1PCNAMDM2ANAPC7
CDC25BCCND2CDK6TGFB1CCNHBUB3PRKDCCDK4YWHAQBUB1B
CDC23MCM2CDC2SMAD3CDC16GADD45ACDC27RBL1ORC5LYWHAZ
SMAD4YWHABMCM3HDAC2
Regulation of actin cytoskeleton (P = 0.0001)LIMK1BDKRB1BDKRB2BRAFSSH1RAC1NCKAP1PPP1CCITGA3PIK3R5
ARPC5PFN1PAK2ITGB3PPP1CAIQGAP3RRAS2TIAM1CFL1PDGFRB
PAK1ABI2ITGB7PXNNRASDIAPH1FGFR1BAIAP2GRLF1GSN
CRKPAK3CSKWASLITGA7ITGA2ITGAVARPC2GNA13MAPK1
Cytokine-cytokine receptor interaction (P = 0.0148)ACVR1BMPR2CCL2IL18R1TNFSF9IL6STPRLRACVR2ATNFRSF12AIL1RAP
PDGFRBCCL7LIFTGFB1PDGFCCLCF1TNFRSF10BTNFRSF10ACD40VEGF
FASCSF1TNFSF15TNFRSF10DTNFSF4TNFSF18
Wnt signaling pathway (P = 0.0391)FZD9FZD8DAAM2RAC1WNT2TP53CSNK2A1CSNK2BPPP3CBCSNK1A1
PSEN1NFAT5WNT5AJUNCCND2TBL1XR1CSNK1EFZD3PLCB1DKK2
SMAD3PPP2CARUVBL1WNT8BCACYBPSMAD4
Axon guidance (P = 0.10337)LIMK1CDK5LRRC4CRAC1PLXNA2PLXNA1PPP3CBNFAT5ABLIM1SEMA4F
PAK2RRAS2CFL1PAK1NRASGNAI3RASA1FYNPAK3UNC5B
NRP1SEMA3AMAPK1
Apoptosis (P = 0.0011)DFFAIRAK3PDCD8BIRC4TP53RIPK1CYCSPPP3CBCAPN2PIK3R5
NFKB1IKBKBBCL2NFKB2IL1RAPTNFRSF10BTNFRSF10AFASCASP7TNFRSF10D
PRKAR2A
Insulin signaling pathway (P = 0.00116)PRKAG2PRKAB1FRAP1EXOC7PPP1CCCALM2PIK3R5IKBKBSOCS6RPS6
MKNK2PPP1CAPCK2RRAS2NRASCALM1PKM2IRS4PYGBIRS1
CRKEIF4EBP1MAPK1PRKAR2A
Gap junction (P = 0.0230)TUBB2CITPR2CSNK1A1ADCY3RRAS2PDGFRBPDGFCCSNK1ETUBA6PLCB1
GNAI3CDC2GNASCSNK1G1GUCY1B3MAPK1TUBB
  • NOTE: Each of these pathways contains >75% induced genes. Among other enriched pathways, containing between 40% and 75% induced genes: ECM-receptor interaction, antigen processing and presentation, calcium signaling pathway, adherens junction, JAK-STAT signaling pathway, Toll-like receptor signaling pathway, and TGF-β signaling pathway.