Table 1.

Metastatic profiles of WM239A variants after primary tumor growth and surgical resection

Sites of metastasisCell lines analyzed
6-4L7-4L8-2L4-5B14-5B2
Brain0/30/40/53/74/6
Lung3/32/44/54/64/5
Kidney1/31/41/50/52/5
Liver0/31/41/50/60/4
  • NOTE: The parental (6-4L), lung metastases–derived (7-4L and 8-2L), and brain metastases–derived (B1 and B2) cell lines were implanted orthotopically; primary tumors mice implanted orthotopically with 131/4-5B1 or 131/4-5B2 cells showed the presence of metastases. All cell lines metastasized efficiently to lung and showed minimal spread to liver and kidney.