Metastatic profiles of WM239A variants after primary tumor growth and surgical resection
| Sites of metastasis | Cell lines analyzed | ||||
|---|---|---|---|---|---|
| 6-4L | 7-4L | 8-2L | 4-5B1 | 4-5B2 | |
| Brain | 0/3 | 0/4 | 0/5 | 3/7 | 4/6 |
| Lung | 3/3 | 2/4 | 4/5 | 4/6 | 4/5 |
| Kidney | 1/3 | 1/4 | 1/5 | 0/5 | 2/5 |
| Liver | 0/3 | 1/4 | 1/5 | 0/6 | 0/4 |
NOTE: The parental (6-4L), lung metastases–derived (7-4L and 8-2L), and brain metastases–derived (B1 and B2) cell lines were implanted orthotopically; primary tumors mice implanted orthotopically with 131/4-5B1 or 131/4-5B2 cells showed the presence of metastases. All cell lines metastasized efficiently to lung and showed minimal spread to liver and kidney.