Table 2.

Genes down-regulated as determined by microarray analyses

Gene and gene IDGene functionPatient no.No. of patients ≥ 1.5
123567891011121314
SFRS 7 6432Shuttles serine/arginine-rich splicing factors, and an adaptor for mRNA nuclear export−1.4−2.1−1.5−2.1−3.3 (−2.2)−4.0−1.5 (−1.1)−1.6 (−1.3)−1.4−3.71.1−2.5 (−1.2)−2.110
SFRS 11 9295Functions in pre-mRNA processing−1.9−2.3−2.51.2−2.0 (−1.8)−2.1−1.6 (−1.4)−3.7 (−1.3)−1.7−4.6−1.1−2.5 (−1.2)1.310
SFRS 5 6430An adaptor for mRNA nuclear export, interacts with export receptor TAP−1.1−1.3−1.2−1.4−1.5−2.0−1.4−2.00.0−1.30.0−1.7−1.75
hnRNPA1 3178Functions in pre-mRNA processing and other aspects of mRNA metabolism and transport−1.2−1.9−1.6−1.5−1.7−1.61.2−2.8−1.9−3.7−2.5−3.3−1.210
IL-18 3606Proinflammatory cytokine, can induce IFN-γ production−2.0−1.7−1.9−2.1−3.5−1.51.1−4.9−1.9−1.7−1.9−1.31.510
ZNF83 55769Serves in zinc binding, nucleic acid binding, and transcription factor activity−2.1−1.3−2.1−1.3−1.7−1.7−1.2−2.5−3.5−2.5−1.3−2.01.77
LGALS8 3964This protein is widely expressed in tumor tissues, involved in integrin-associated cell interactions−3.01.1−1.2−1.9−3.3 (−2.3)−2.5−1.3 (−1.1)−2.6 (−1.5)−1.6−1.9−1.9−1.6 (−1.4)1.69
DUSP5 1847Negative regulator of mitogen-associated protein kinase superfamily, dephosphorylates phosphorylated serine, threonine and tyrosine residues−1.6−1.6−1.11.2−2.3−2.8−2.9−2.3−1.2−2.51.1−1.3−4.08
CLK1 1195Functions in splicing site selection in the nucleus−1.3−2.1−2.01.1−2.1−1.3−1.5−1.7−1.2−3.3−1.4−2.6−1.47
MRS2L 57380Mg2+ transporter which maintains mitochondrial Mg2+ concentrations−1.9−1.9−1.3−1.2−2.5−1.4−2.3−2.1−1.5−2.5−1.9−1.31.28
RNASET2 8635A secreted RNase, associated with human cancers and chromosomal rearrangement−2.1−1.6−2.3−1.2−1.71.5−1.1−2.3−2.1−2.3−1.9−2.0−1.29
TBCE 6905Protein used β-tubulin folding and microtubule formation, trafficking of golgi and endosomal proteins−1.7−2.5−1.7−1.2−1.9−1.6−1.3−2.00.0−1.9−2.6−2.11.49
SFPQ 6421Polypyrimidine tract binding protein-splicing factor proline/glutamine-rich−1.2−1.6−2.0−1.6−3.3−1.40.0−2.5−1.1−3.5−1.3−1.51.17
CCNL2 81669Functions in transcription and RNA processing−1.2−1.21.1−2.0−2.5−2.5−1.6−3.31.1−3.0−1.1−1.4−1.36
SLC25A28 81894Mitochondrial protein involved in solute transport−1.11.1−1.2−1.2−2.6−2.6−1.7−2.3−1.7−2.8−1.2−1.5−1.27
CTSL2 1515Lysosomal cysteine protease, putatively functions in growth factor recycling, increased expression in cancers−1.9−1.6−1.4−2.8−2.8−1.4−1.9−1.5−1.4−1.5−1.21.7−1.37
GAPDS 26330Gyceraldehyde-3 phosphate dehydrogenase, generates 1,3 diphosphoglycerate−1.9−2.01.3−1.9−1.7−2.80.0−1.4−1.5−1.7−1.3−2.01.18
WIPI49 55062Regulates the assembly of multiprotein complexes and interacts with phospholipids−1.7−3.3−1.4−1.2−1.6−1.3−1.9−1.3−1.2−2.31.2−1.7−1.26
PIGL 9487Functions in phosphatidylinositol glycan synthesis−1.4−2.00.01.2−1.9−2.5−1.9−1.9−1.2−2.3−1.2−1.70.07
MRPL48 51642Mitochondrial ribosomal protein, assists in mitochondrial protein synthesis−1.7−1.90.0−1.3−2.0−1.3−1.4−1.5−1.1−2.6−1.3−1.4−1.25
RBM34 23029RNA binding motif protein 34−1.9−1.9−1.4−1.3−1.9−1.1−1.3−1.9−1.4−2.81.2−1.61.26
MRPS31 10240Mitochondrial ribosomal protein S31, functions in translation initiation−1.2−1.9−1.11.1−1.9−1.2−1.2−2.1−1.5−1.6−2.3−1.60.07
CFLAR 8897Serves as an inhibitor of apoptosis, speculated to function as a tumor progression factor−1.2−1.6−1.5−1.1−1.3−2.0−1.7−1.91.2−1.4−1.4−1.3−2.15
MED6 10001Mediator of RNA polymerase I transcription−1.4−1.2−1.2−1.4−2.0−1.5−1.5−2.3−1.2−1.71.2−1.2−1.35
NACA 4666Serves as a transcriptional coactivator and augments AP-1 activity−1.2−2.1−2.0−1.7−2.3−2.0−1.3−1.2−1.5−2.31.1−2.31.48
KIAA0117 23029Nucleolus associated RNA binding motif protein−1.9−1.9−1.41.3−1.9−1.1−1.3−1.9−1.4−2.81.2−1.61.26
PTS 5805Functions in tetrahydrobioterin synthesis, serves as a cofactor for nitric oxide synthase isoforms−1.1−1.7−1.5−1.6−2.1−1.5−1.2−1.9−1.1−2.00.0−1.51.28
  • NOTE: Data expressed as fold change in the posttreatment tissues relative to participant-matched pretreatment tissues. Values in parentheses are confirmatory data obtained by quantitative RT-PCR (patient nos. 6, 8, 9, and 13).