Table 2.

Cox regression analyses of metagene expression in relation to time to metastasis in the Mainz (A), Rotterdam (B), and TRANSBIG (C) cohorts

(A) Mainz
MetageneAll data (n = 200; 47 events)High proliferation (n = 95; 31 events)Low proliferation (n = 105; 16 events)
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Univariate
    T-Cell0.80 (0.53–1.19)0.2630.61 (0.38–0.98)0.0410.99 (0.38–2.6)0.986
    B-Cell0.84 (0.68–1.03)0.0950.70 (0.53–0.94)0.0181.16 (0.83–1.62)0.395
    Proliferation2.30 (1.64–3.24)<0.0012.2 (1.36–3.57)0.0013.6 (0.3–43.46)0.313
    ER0.47 (0.24–0.92)0.0280.8 (0.33–1.89)0.6050.62 (0.12–3.20)0.571
Multivariate
    T-Cell0.83 (0.50–1.39)0.480.93 (0.53–1.61)0.7830.47 (0.12–1.80)0.269
    B-Cell0.79 (0.61–1.04)0.0930.66 (0.46–0.97)0.0341.41 (0.90–2.20)0.136
    Proliferation2.20 (1.40–3.46)<0.0012.02 (1.14–3.59)0.0167.06 (0.49–101)0.151
    ER0.63 (0.26–1.56)0.3180.61 (0.21–1.79)0.3650.54 (0.08–3.58)0.519
(B) Rotterdam
MetageneAll data (n = 286; 106 events)High proliferation (n = 184; 77 events)Low proliferation (n = 102; 29 events)
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Univariate
    T-Cell0.77 (0.60–0.98)0.0360.66 (0.48–0.89)0.0061.00 (0.65–1.53)0.999
    B-Cell0.78 (0.65–0.94)0.0090.71 (0.57–0.89)0.0030.95 (0.73–1.25)0.701
    Proliferation1.53 (1.17–2.01)0.0021.30 (0.79–1.92)0.18321.7 (0.29–61.7)0.016
    ER0.61 (0.38–0.98)0.0420.80 (0.45–1.44)0.460.63 (0.27–3.35)0.403
Multivariate
    T-Cell0.80 (0.5–1.15)0.220.74 (0.48–1.13)0.1590.88 (0.45–1.73)0.719
    B-Cell0.78 (0.62–0.98)0.0340.74 (0.56–0.97)0.030.91 (0.64–1.29)0.6
    Proliferation1.27 (0.88–1.82)0.1971.01 (0.62–1.63)0.97623.2 (1.77–305)0.017
    ER0.50 (0.25–1.00)0.0480.46 (0.21–1.01)0.0530.58 (0.15–2.24)0.428
(C) TRANSBIG
MetageneAll data (n = 302; 77 events)High proliferation (n = 151; 54 events)Low proliferation (n = 151; 23 events)
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Univariate
    T-Cell0.79 (0.59–1.05)0.1010.62 (0.44–0.86)0.0040.99 (0.55–1.77)0.96
    B-Cell0.85 (0.75–0.97)0.0190.78 (0.66–0.91)0.0010.98 (0.80–1.20)0.86
    Proliferation1.35 (1.00–1.82)0.0490.53 (0.30–0.95)0.0344.47 (0.47–42.6)0.192
    ER0.64 (0.38–1.07)0.0892.02 (1.06–3.84)0.0320.15 (0.03–0.62)0.009
Multivariate
    T-Cell0.86 (0.6–1.23)0.4180.83 (0.55–1.26)0.3840.63 (0.25–1.54)0.306
    B-Cell0.83 (0.7–0.97)0.0210.82 (0.68–0.99)0.0351.01 (0.78–1.30)0.942
    Proliferation1.17 (0.77–1.79)0.4630.68 (0.30–1.18)0.1353.68 (0.42–32.1)0.24
    ER0.49 (0.22–1.09)0.080.69 (0.30–1.82)0.5100.10 (0.02–0.48)0.004