Table 1.

Risk of developing second primary breast cancer associated with ATM gene carrier status

ATM variants classificationCases (n)Controls (n)Rate ratio * (95% CI)
Overall
    Wild-type2714801.0
    Carrier of any ATM variant4379170.8 (0.7–1.0)
Common
    Wild-type2714801.0
    Carrier of any common ATM variant3557780.8 (0.6–0.9)
Rare
    Wild-type2714801.0
    Carrier of any rare ATM variant1482641.0 (0.8–1.4)
  • * Adjusted for exact age at diagnosis of the first primary and countermatching weight. Common and rare models also adjusted for carriers of other remaining ATM variants.

  • Common variants are defined as those carried by ≥1% of the WECARE Study participants. Rare variants are those carried by <1% of the participants.