Table 1.

Summary of PIK3CA mutations in lung cancers

ExonAmino acid changeFunctional domainNSCLC cell lines (n = 86)NSCLC tumors (n = 691)SCLC cell lines (n = 43)ExPuSC cell lines (n = 3)Total no. mutations
9S541FHelical01 *001
9E542KHelical02 *002
9E545KHelical25007
9Q546KHelical10001
20M1043LKinase01001
20H1047RKinase11013
20H1047LKinase02013
Total cell lines/tumors (%)4 (4.7%)11 * (1.6%)0 (0%)2 (66.7%)
  • * One NSCLC tumor had both S541F and E542K mutations. For histologic subtype data of cell lines, see Table 2. Mutations in the 691 NSCLC tumors occurred in the following histologic subtypes: 5 of 249 (2.0%) squamous cell tumors, 5 of 400 (1.3%) adenocarcinomas, and 1 of 42 (2.4%) other NSCLC tumors.