Table 1.

Mutation status of endometroid endometrial tumors

Case IDFGFR2 MutationKRAS MutationPTEN MutationStageGradeMSI
AN3CAp.[Lys310Arg(+)Asn550Lys]WTp.Arg130fsX4+
MFE296p.Asn550LysWTWT
1359p.Ser252TrpWTWTI2+
1574p.Ser252TrpWTp.[Gly44AlafsX7(+)Y68X]I2+
1492p.[Ser252Trp(+)Tyr376Cys]WTp.Arg130GlyI1
1484p.Ser252TrpWTp.[Arg130Gly(+)F56V]III3
1316p.Ser252TrpWTp.Leu112ValIII1
1792p.Ser252TrpWTwtIII1+
1482p.Ser252TrpWTp.Thr319XIV2+
1267p.Asn550LysWTp.AlaA126AspII2+
1391p.Asn550LysWTp.Q245XIII2+
1528p.Asn550LysWTp.Arg130GlyIV2
1655p.Tyr376CysWTp.Arg308llefsX5III2+
1684p.Ser373CysWTp.Arg130GlyI1+
1094p.Cys383ArgWTp.Leu108-Asp109I1+
1361p.Met392ArgWTp.Thr319XI1+
1744p.lle548ValWTp.[Phe21SerfsX2(+)K66N]III2+
1717p.Lys660GluWTp.Ser59XI2
1272c.1287+2A>CWTWT11
1289p.Thr762fsX3p.Gly12AspWTI3+
1284WTp.Gly12Aspp.[Arg130Gly(+)Gly165Arg]II1+
1606WTp.Gly12Aspp.Val191GlyfsX7I1
1856WTp.Gly12AspwtI2+
1411WTp.Gly12Alap.[Arg47Gly(+)Gly165Arg]III2+
1966WTp.Gly12Alap.[Arg130X(+)Ala148LysfsX3]III2+
1393WTp.Gly12Cysp.lle4HisfsX5III2+
1609WTp.Gly12Cysp.Lys267ArgfsX8I3+
1044WTp.Gly12Valp.Arg130GlnIII3+
1599WTp.Gly12Valp.[Arg130Gly(+)Gln171X]III2+
1873WTp.Gly12Valp.V290XI1+
1656WTp.Gly12Valp.Gly251ValfsX5II
1664WTp.Gly12Aspp.Tyr16LeufsX27IIII
1287WTp.Gly13Aspp.[H123Y(+)Ala126Ser]III1
1576WTp.Gly13Aspp.Arg130GlnI2+
  • NOTE: Numbering relative to FGFR2 protein sequence NP_075259.2, KRAS protein sequence NP_203524.1, and PTEN protein sequence NP_000305.3.