Table 1.

Effects of TGF-β1 on telomere shortening and chromosomal instability

Cell linePDTelomere signal–free ends (%)Chr. in end-fusions/100 cellsChr. in other nonclonal structural aberrations/100 cells *ABF (%)Chr. in clonal structural aberrations/100 cells
NC104-E6E7140.261242
280.181452
400.141532
70021622
NC105-E6E7140.161630
240.0661440
400.0421230
70021531
NC104-E6E7(TGF-β1)143.37423130
28 9.0356174302
400.1818610
700.11020510
NC105-E6E7(TGF-β1)142.68231111
24 8.1307212351
400.21016711
700.1614513
  • Abbreviations: Chr., chromosomes; ABF, anaphase bridge frequency.

  • * Including nonreciprocal translocations, deletions, duplications, and intra-arm dicentrics.

  • Crisis.