Table 2.

Geometric means (95% confidence intervals) for nicotine equivalents and NNK internal dose by CHRNA3 and CHRNA5 genotype in the Hawaii study

GeneGenotypeNicotine equivalentsTotal NNAL *
nAge-, sex-, and race-adjusted model CPD-adjusted model nMean (95% CI)P§PP
Mean (95% CI)P§PPMean (95% CI)P§PP
CHRNA3 (rs1051730)GG39359.0 (55.4–62.6)0.0040.010.2059.1 (55.7–62.6)0.0040.010.313901.20 (1.13–1.27)0.140.330.58
GT15768.7 (62.6–75.1)70.2 (57.5–84.3)1561.31 (1.19–1.45)
TT3172.3 (59.0–87.0)70.2 (57.5–84.3)311.32 (1.06–1.65)
CHRNA5 (rs16969968)GG39364.2 (57.7–71.1)0.0030.010.0959.2 (55.8–62.6)0.0030.010.153901.19 (1.12–1.27)0.040.110.26
AG15961.0 (53.9–68.6)68.6 (62.8–74.7)1581.33 (1.21–1.47)
AA3178.0 (71.7–84.5)73.3 (60.2–87.5)311.42 (1.14–1.77)
  • Abbreviations: CPD, cigarettes per day; 95% CI, 95% confidence interval.

  • * Sum of urinary NNAL and NNAL-Gluc (in pmol/mg creatinine), adjusted for age, sex, race/ethnicity, and cigarettes per day.

  • Sum of urinary nicotine, cotinine, 3-HC, and their respective glucuronides (in nmol/mg creatinine), adjusted for age, sex, and race/ethnicity.

  • Further adjusted for cigarettes per day and BMI.

  • § P for dominant model of inheritance.

  • P for additive model of inheritance.

  • P for recessive model of inheritance.