Table 3.

Geometric means (95% confidence intervals) for nicotine equivalents and total NNK exposure by CHRNA5 genotype in two UMN studies and in all studies combined

Studyrs16969968 genotypeNicotine equivalentsTotal NNAL *
nAge-adjusted model Multivariate model nMean (95% CI)P§PP
Mean (95% CI)P§PPMean (95% CI)P§PP
UMN-1GG4190.3 (58.4–129.2)0.720.410.2693.5 (61.0–132.8)0.470.310.28413.00 (2.38–3.77)0.310.210.09
AG4881.5 (48.9–122.2)79.4 (47.4–119.7)483.14 (2.44–4.04)
AA10108.5 (59.8–171.6)107.6 (59.4–170.0)103.81 (2.73–5.31)
UMN-2GG7449.7 (37.0–64.2)0.300.380.2053.1 (40.8–67.2)0.360.420.21731.89 (1.66–2.15)0.830.960.94
AG4353.5 (36.9–73.2)56.1 (40.0–74.9)431.86 (1.59–2.17)
AA2063.1 (41.6–89.1)65.4 (44.7–90.0)201.89 (1.57–2.27)
All **GG50860.5 (54.2–68.1)0.0030.0050.0261.2 (54.2–68.7)0.010.020.045041.48 (1.32–1.65)0.030.090.21
AG25067.0 (58.1–76.6)66.7 (58.1–76.0)2491.59 (1.40–1.80)
AA6177.7 (64.2–92.4)76.1 (63.2–90.3)611.70 (1.42–2.04)
  • * Sum of urinary NNAL and NNAL-Gluc (in pmol/mg creatinine), adjusted for age, sex, race/ethnicity, and cigarettes per day.

  • Sum of urinary nicotine, cotinine, 3-HC, and their respective glucuronides (in nmol/mg creatinine), adjusted for age, sex, and race/ethnicity.

  • Further adjusted for cigarettes per day and BMI.

  • § P for dominant model of inheritance.

  • P for additive model of inheritance.

  • P for recessive model of inheritance.

  • ** Models are further adjusted for study.