Table 1.

Gene expression of apoptosis-related ligands and receptors in MIP-101 cells

Apoptosis-related ligandsStatic 3D versus 2DApoptosis-related receptorsStatic 3D versus 2D
FasL2.03Fas
CD40L/CD1541.05CD401.57
TRAIL1.74TRAIL-R1, DR4
RANKL1.69TRAIL-R2, DR52.07
TRAIL-R3 Decoy-DcR10.54
TRAIL-R4 Decoy-DcR20.99
TNFRSF11A0.72
Osteoprotegrin2.25
CD301.06
CD271.77
  • NOTE: MIP-101 cells were cultured for 24 h in monolayers (2D) and in static suspension culture (static 3D). Cells were harvested, total RNA was isolated, and gene expression was analyzed on proprietary chips that contain ∼14,473 genes. Comparisons among the different growth conditions are presented, the results represent the combined data from at least two separate experiments performed in triplicate, and relative gene expression for the comparisons was indicated. Changes in expression of ±0.5 are significant. Only those changes that are 2-fold or greater are in bold font.