Table 1.

KEAP1 alterations in lung cancer tissues and cell lines

Patients/cell linesPathologyAmino acid changeDomain
P1SCCA427V (heterozygous)DGR
P9ADCH200P (heterozygous)IVR
P12ADCG430C (heterozygous)DGR
P23ADCR415G (heterozygous)DGR
P65LCCG476R (homozygous)DGR
H2126ADCR272C (homozygous)IVR
H1648ADCG364C (homozygous)DGR
  • Abbreviations: SCC, small cell carcinomas; ADC, adenocarcinomas; LCC, large cell carcinomas.