Table 1.

List of the top eight gene sets enriched in the gemcitabine-sensitive and CI1040-sensitive tumors with nominal P value of ≤0.05

NameKEGG pathways enriched in sensitive tumorsSizeESNESNOM p-valFDR q-val
Gemcitabine
    HSA00591Linoleic acid metabolism350.581.590.0211.00
    HSA00920Sulfur metabolism130.641.590.0270.84
    HSA00603Glycosphingolipid biosynthesis140.581.560.0410.69
    HSA04740Olfactory transduction310.501.550.0200.58
    HSA00360Phenylalanine metabolism290.511.530.0290.54
    HSA03320PPAR signaling pathway660.461.510.0260.52
    HSA00590Arachidonic acid metabolism520.531.510.0500.45
    HSA00340Histidine metabolism390.441.460.0450.56
CI1040
    HSA05211Renal cell carcinoma690.471.820.0040.114
    HSA05040Huntington's disease310.521.760.0060.146
    HSA00740Riboflavin metabolism160.601.620.0260.398
    HSA05220Chronic myeloid leukemia760.411.590.0060.387
    HSA05212Pancreatic cancer730.411.570.0290.377
    HSA05210Colorectal cancer850.421.530.0300.439
    HSA04520Adherens junction790.361.500.0380.484
    HSA04910Insulin signaling pathway1350.291.330.0400.903
  • NOTE: The gene list is sorted descending with NES score. In the gemcitabine table, it is noteworthy the lower statistical significance compared with Fig. 3A.

    Abbreviation: size, number of genes in the gene set; ES, enrichment score; NES, normalized enrichment score; NOM p-val, nominal P value; FDR q-val, FDR.