Table 1.

List of the top eight gene sets enriched in the gemcitabine-sensitive and CI1040-sensitive tumors with nominal P value of ≤0.05

Name	KEGG pathways enriched in sensitive tumors	Size	ES	NES	NOM p-val	FDR q-val
Gemcitabine
HSA00591	Linoleic acid metabolism	35	0.58	1.59	0.021	1.00
HSA00920	Sulfur metabolism	13	0.64	1.59	0.027	0.84
HSA00603	Glycosphingolipid biosynthesis	14	0.58	1.56	0.041	0.69
HSA04740	Olfactory transduction	31	0.50	1.55	0.020	0.58
HSA00360	Phenylalanine metabolism	29	0.51	1.53	0.029	0.54
HSA03320	PPAR signaling pathway	66	0.46	1.51	0.026	0.52
HSA00590	Arachidonic acid metabolism	52	0.53	1.51	0.050	0.45
HSA00340	Histidine metabolism	39	0.44	1.46	0.045	0.56
CI1040
HSA05211	Renal cell carcinoma	69	0.47	1.82	0.004	0.114
HSA05040	Huntington's disease	31	0.52	1.76	0.006	0.146
HSA00740	Riboflavin metabolism	16	0.60	1.62	0.026	0.398
HSA05220	Chronic myeloid leukemia	76	0.41	1.59	0.006	0.387
HSA05212	Pancreatic cancer	73	0.41	1.57	0.029	0.377
HSA05210	Colorectal cancer	85	0.42	1.53	0.030	0.439
HSA04520	Adherens junction	79	0.36	1.50	0.038	0.484
HSA04910	Insulin signaling pathway	135	0.29	1.33	0.040	0.903

NOTE: The gene list is sorted descending with NES score. In the gemcitabine table, it is noteworthy the lower statistical significance compared with Fig. 3A.

Abbreviation: size, number of genes in the gene set; ES, enrichment score; NES, normalized enrichment score; NOM p-val, nominal P value; FDR q-val, FDR.