Mutation patterns identified for the EGFR, KRAS, and PI3KCA genes and gene amplifications in EGFR and HER2 in pancreatic cancer tumors
| Cases | EGFR | KRAS | BRAF | PIK3CA | EGFR FISH | HER2 FISH |
|---|---|---|---|---|---|---|
| Learning set | ||||||
| 198 | wt | mut | wt | wt | 1 | 1 |
| 410 | wt | wt | wt | mut | 5 | 5 |
| 286 | wt | mut | wt | wt | 2 | 2 |
| 140 | wt | mut | wt | wt | 5 | 6 |
| 163 | wt | mut | wt | wt | 4 | 4 |
| 287 | wt | wt | wt | wt | 5 | 5 |
| 253 | wt | mut | wt | wt | 4 | 4 |
| 194 | wt | mut | wt | wt | 4 | 2 |
| 265 | wt | mut | wt | wt | 2 | 4 |
| 215 | wt | mut | wt | wt | 5 | 4 |
| Validation set | ||||||
| 219 | wt | mut | wt | wt | 2 | 3 |
| 294 | wt | mut | wt | wt | 4 | 4 |
| 281 | wt | mut | wt | wt | 5 | 6 |
| 247 | wt | mut | wt | wt | 5 | 5 |
| 185 | wt | mut | wt | wt | 5 | 4 |
| 159 | wt | mut | wt | wt | 4 | 1 |
| 354 | wt | wt | wt | wt | 2 | 2 |
NOTE: Sensitive cases are shown in bold.
Abbreviations: wt, wild type; mut, mutant.