Table 2.

Acute biodistribution in LNCaP-bearing mice split into two groups: (a) mice that received 150 mmol/L bicarbonated water at pH 8.0 ad libitum for 7 d before the study and (b) mice fed regular drinking water

4 h (untreated)4 h (modulated)
Blood7.21 ± 1.397.27 ± 1.00
Lung3.63 ± 0.633.85 ± 0.61
Liver5.29 ± 1.645.79 ± 0.66
Spleen1.49 ± 0.321.53 ± 0.25
Kidney *5.20 ± 1.063.78 ± 0.29
Muscle0.69 ± 0.401.05 ± 0.80
Skin1.12 ± 0.291.02 ± 0.27
Fat1.26 ± 1.421.16 ± 0.50
Heart2.07 ± 0.282.39 ± 0.44
Brain0.59 ± 0.690.27 ± 0.06
Bone1.22 ± 1.152.22 ± 2.51
Pancreas1.48 ± 0.771.56 ± 0.67
Stomach0.88 ± 0.581.01 ± 0.26
Small intestine2.05 ± 1.042.48 ± 0.59
Upper large intestine2.35 ± 1.253.55 ± 1.94
Lower large intestine1.28 ± 0.791.23 ± 0.54
LNCaP *4.50 ± 1.711.31 ± 0.60
  • NOTE: Data are %ID/g ± SD in n = 4 mice per group.

  • * P < 0.005, statistical significance between treated and nontreated groups.