Table 2.

Independent SNPs that are associated with aggressive prostate cancer in CAPS and CGEMS

CHRSNPCAPS-GWASCGEMSMantel-HaenszerCAPS-500/500
PositionAlleleAggressive cases (n = 498)Controls (n = 494)P*OR*Type of SNPs% missing dataAggressive cases (n = 983)Controls (n = 527)P*OR*Type of SNPs% missing dataP combinedAggressive cases (n = 500)Controls (n = 500)P*OR*
1rs11580380102,371,869A0.110.090.081.34Imputed0.020.110.078.99E−051.58Imputed0.019.51E−050.090.120.080.77
4rs96847406,066,865A0.340.441.63E−050.65Imputed0.000.370.390.12830.90Imputed0.032.94E−050.400.380.581.05
4rs4466060131,939,926C0.180.150.111.25Imputed0.070.200.154.30E−051.45Imputed0.006.08E−05
4rs10032223190,115,687T0.230.154.05E−051.68Imputed0.010.210.190.14661.13Imputed0.027.73E−050.180.200.100.90
5rs254803533,853,908C0.390.492.47E−050.66Imputed0.020.450.470.15310.91Imputed0.005.11E−050.470.450.311.10
5rs6580317143,752,911C0.190.230.030.76Genotyped0.090.190.251.15E−040.71Imputed0.094.66E−050.250.240.501.07
5rs4448013162,585,129T0.150.190.020.73Imputed0.020.150.203.47E−040.71Genotyped0.058.12E−050.140.130.251.16
7rs22177099,946,745A0.170.109.75E−051.77Genotyped0.040.130.090.003311.38Imputed0.005.15E−060.130.150.250.87
9rs15354535,400,624C0.050.021.84E−043.04Imputed0.060.050.030.028261.46Genotyped0.046.84E−050.070.060.611.10
9rs455932738,727,017C0.360.320.111.19Imputed0.080.350.284.16E−051.37Imputed0.086.27E−05
9rs1012355389,934,974C0.400.507.57E−050.68Imputed0.000.430.460.071770.88Imputed0.017.13E−050.470.460.731.03
10rs133554026,767,244T0.280.371.85E−040.66Imputed0.100.350.390.018420.84Imputed0.064.64E−050.360.360.941.00
10rs791383836,639,228C0.070.043.28E−031.97Imputed0.010.080.060.001821.53Imputed0.047.76E−050.070.060.611.10
12rs4576883118,152,179G0.100.154.88E−030.65Imputed0.000.100.140.001060.70Imputed0.016.79E−050.200.230.130.85
13rs732746139,961,028G0.190.125.20E−041.63Imputed0.060.170.140.013641.28Genotyped0.079.11E−050.190.170.501.08
14rs233238970,032,772T0.090.070.171.29Imputed0.010.140.096.61E−061.63Imputed0.001.65E−05
14rs1712729690,908,001A0.060.040.031.70Imputed0.090.060.042.45E−041.77Imputed0.019.00E−050.040.040.841.05
16rs74367213,814,689G0.050.027.91E−032.05Imputed0.000.080.057.28E−051.77Genotyped0.018.84E−060.060.040.141.36
20rs727118637,291,509A0.090.052.35E−031.82Imputed0.050.090.060.00131.52Genotyped0.014.16E−050.080.080.310.89
21rs658624342,109,475T0.060.109.45E−040.54Imputed0.060.080.125.32E−040.66Imputed0.067.79E−060.130.120.911.02
22rs729169138,778,569G0.240.190.011.37Imputed0.040.250.204.05E−041.34Imputed0.015.61E−050.230.190.041.25
  • NOTE: P* and OR*: based on allelic test assuming multiplicative model.