Mean distribution volume and K1 values of [methyl-11C]temozolomide in human tissue
| ROI | n | m | VD(1) | VD(2) | K1 (s−1) | MRT (s) |
|---|---|---|---|---|---|---|
| Normal Brain | 7 | 58 | 0.93 (0.46) | 0.52 (0.08) | 0.033 (0.016) | 39 (31) |
| Tumor | 7 | 58 | 1.41 (0.58) | 0.92 (0.11) | 0.052 (0.025) | 38 (30) |
| Parameter values excluding contribution from blood volume | ||||||
| Normal Brain | 7 | 58 | 0.90 (0.46) | 0.0003 (0.0001) | 3,400 (1,600) | |
| Tumor | 7 | 58 | 1.35 (0.58) | 0.0016 (0.0009) | 1,000 (600) | |
NOTE: VD(1), K1, and MRT (mean residence time) were calculated using spectral analysis ( 12) and averaging over m slices from scans of n patients; VD(2) was calculated using the rank-shaped estimator ( 28). Tissue pharmacokinetic parameters derived with and without contribution of regional blood volume are presented. The SDs are in parentheses.
Abbreviation: ROI, region of interest.