Table 1.

Patient characteristics

(A) Study population characteristics
Pilot studyTraining setValidation set
Number of study subjects (N)307196
Age (y)Mean (y)
    CRC60.769.371.1
    Adenoma55.161.4
    Controls54.25552.3
SexPercentage
    Male605245
    Female404654
    Unknown21
(B) Summary of test performance
Pilot study (n = 30)Training set (n = 71)Validation set (n = 96)
CRCn = 11n = 26n = 47
    Sensitivity (95% CI)73 (39–94)89 (70–98)76 (60–88)
    Specificity (95% CI)100 (74–100)79 (64–90)93 (77–99)
    PPV (95% CI)100 (63–100)72 (53–86)94 (80–99)
    NPV (95% CI)80 (52–96)92 (78–98)73 (56–86)
Adenoman = 7n = 19
    Sensitivity (95% CI)43 (10–82)21 (6–46)
    Specificity (95% CI)100 (74–100)93 (78–99)
    PPV (95% CI)100 (29–100)67 (22–96)
    NPV (95% CI)75 (48–93)65 (49–79)
  • Abbreviations: PPV, positive predictive value; NPV, negative predictive value; 95% CI, 95% confidence interval.