Table 1.

Inhibition of cyclin-dependent protein kinase activity by BS-181

KinaseRoscovitine IC50, μmol/L (SD)BS-181 IC50, μmol/L (SD)
CDK70.51 (0.1)0.021 (0.002)
CDK11.8 (0.3)8.1 (0.6)
CDK20.1 (0.02)0.88 (0.08)
CDK415.3 (6.6)33 (1.5)
CDK50.24 (0.1)3.0 (0.5)
CDK628 (4.9)47 (4)
CDK91.2 (0.8)4.2 (0.5)
  • NOTE: The mean IC50 values (μmol/L) for roscovitine and BS-181, obtained from three experiments, are shown together with the SD from the mean. The line graphs from which IC50 values were obtained are shown in Supplementary Fig. S2.