Table 2.

Association between 15q25.1 (rs12914385, rs8042374, and rs938682), 5p15.33 (rs4975616, rs2736100), 6p21.33 (rs3117582), and lung cancer histology in combined analysis of UK-GWA study phases 1 and 2

SCLCNSCLC
AllAllAdenoSquamousOtherSCLC vs NSCLCAdeno vs Squamous
SNPnMAFnMAFnMAFnMAFnPOR (95%CI)POR (95% CI)
15q25.1
    rs12914385 (CHRNA3)1,0350.443,3440.449030.431,6770.447640.711.02 (0.92–1.13)0.630.97 (0.87–1.09)
    rs8042374 (CHRNA3)1,0330.193,3390.199010.201,6750.187640.760.98 (0.86–1.11)0.201.10 (0.95–1.27)
    rs938682 (CHRNA3)1,0350.193,3450.199030.201,6780.187640.781.02 (0.90–1.16)0.180.91 (0.78–1.05)
5p15.33
    rs4975616 (CLPTM1L)1,0350.403,3400.399010.381,6750.397640.461.04 (0.94–1.15)0.850.99 (0.88–1.11)
    rs2736100 (TERT)1,0340.513,3430.479030.441,6770.497640.00111.18 (1.07–1.30)7.2 × 10−40.82 (0.73–0.92)
6p21.33
    rs3117582 (BAT3)1,0340.143,3420.169030.141,6770.177640.150.90 (0.79–1.04)0.020.83 (0.71–0.98)