Table 3.

Association between smoking behavior and genotype, (b) allele frequency

A. Association between smoking behavior and genotype
15q25.1
CasesControls
nMean CPDP *nMean CPDP *
rs12914385
    CC1,23021.5937318.13
    CT1,97322.1941318.46
    TT 81523.913.7 × 10−312118.530.17
rs8042374
    AA 2,64922.6554118.57
    AG1,21921.9631418.00
    GG14420.162.4 × 10−35217.860.48
rs938682
    TT 2,64822.6654218.09
    CT1,22921.9831217.89
    CC14219.991.8 × 10−35318.610.37
5p15.33
rs4975616
    AA 1,49122.3330117.65
    AG1,89322.5745518.91
    GG63021.770.7815117.970.56
rs2736100
    GG 107122.1921718.17
    GT2,00921.4145718.35
    TT93622.420.9523318.450.94
6p21.33
rs3117582
    AA2,89222.3667918.30
    AC1,00822.3520918.45
    CC 11522.270.541918.110.97
B. Association between smoking behavior and allele frequency
15q25.1
rs12914385
    Cig/d
    1–181,4600.424790.34
    19–241,3490.442540.39
    25+1,2090.486.7 × 10−51740.370.16
rs8042374
    Cig/d
    1–181,4580.214790.24
    19–241,3480.182540.23
    25+1,2060.171.2 × 10−31740.220.46
rs938682
    Cig/d
    1–181,4600.214790.24
    19–241,3500.182540.23
    25+1,2090.179.0 × 10−41740.220.46
5p15.33
rs4975616
    Cig/d
    1–181,4580.384790.40
    19–241,3490.402540.45
    25+1,2080.390.551740.410.52
rs2736100
    Cig/d
    1–181,4600.524790.49
    19–241,3480.532540.49
    25+1,2080.510.651740.50.78
6p21.33
rs3117582
    Cig/d
    1–181,4590.164790.13
    19–241,3480.152540.14
    25+1,2080.150.561740.140.79
  • NOTE: Association between 15q25.1 (rs12914385, rs8042374, rs938682), 5p15.33 (rs4975616, rs2736100), 6p21.33 (rs3117582), and smoking behavior assessed by studying the relationship with consumption of CPD. Complete CPD information was available for 4019 UK-GWA study (phases 1 and 2) cases and 907 UK-GWA study phase 2 control samples. CPD were categorized into different smoking quantities: 1 to 18 CPD, 19 to 24 CPD, 25 or more CPD; strata defined to ensure number of individuals in each approximately equal.

    Abbreviation: Adeno, adenocarcinoma; cig/d, cigarettes per day.

  • * From Kruskall-Wallis test.

  • Risk genotype.

  • From trend test.