Table 2.

Chromosome 15 association results for selected SNPs, sorted by chromosomal position

SNPAfrican-American sampleEuropean-American sampleFull sampleCross-population heterogeneity
OR (95% CI)POR (95% CI)POR (95% CI)PP
rs174835481.58 (0.95–2.61)7.98E−21.36 (1.19–1.54)5.95E−61.36 (1.20–1.54)1.88E−66.17E−01
rs174052171.78 (1.04–3.04)3.45E−21.35 (1.18–1.54)7.50E−61.37 (1.20–1.55)1.55E−63.56E−01
rs26560520.97 (0.78–1.20)7.90E−11.27 (1.11–1.44)3.84E−41.18 (1.06–1.32)3.05E−35.38E−02
rs174842351.79 (1.05–3.05)3.36E−21.36 (1.19–1.54)5.25E−61.37 (1.21–1.55)1.06E−63.62E−01
rs71645941.00 (0.80–1.25)9.79E−10.74 (0.64–0.86)1.10E−40.81 (0.71–0.91)1.04E−33.35E−02
rs80341911.32 (0.96–1.80)8.84E−21.37 (1.20–1.56)2.30E−61.36 (1.21–1.53)5.59E−78.47E−01
rs105192031.13 (0.88–1.44)3.45E−11.33 (1.17–1.51)1.62E−51.29 (1.15–1.44)1.65E−52.98E−01
rs20365340.89 (0.69–1.15)3.88E−10.75 (0.64–0.87)2.77E−40.79 (0.69–0.89)3.40E−42.56E−01
rs129164830.86 (0.64–1.15)3.16E−10.94 (0.83–1.06)3.57E−10.93 (0.83–1.04)2.11E−15.15E−01
rs38135700.82 (0.64–1.04)1.09E−10.75 (0.64–0.87)2.35E−40.77 (0.68–0.87)7.39E−55.36E−01
rs118582300.86 (0.67–1.10)2.37E−10.93 (0.82–1.05)2.65E−10.92 (0.82–1.02)1.30E−15.37E−01
rs20365271.36 (1.04–1.78)2.37E−21.37 (1.21–1.56)1.81E−61.37 (1.22–1.53)1.41E−79.57E−01
rs6672820.90 (0.71–1.14)3.99E−10.75 (0.64–0.87)1.68E−40.79 (0.69–0.89)2.03E−42.28E−01
rs5887650.80 (0.63–1.00)5.48E−20.91 (0.80–1.02)1.18E−10.88 (0.79–0.98)2.56E−23.56E−01
rs64953060.80 (0.63–1.00)5.29E−20.90 (0.80–1.02)1.16E−10.88 (0.79–0.98)2.44E−23.45E−01
rs174862781.28 (1.01–1.63)4.43E−21.40 (1.23–1.59)5.74E−71.37 (1.22–1.54)6.77E−86.12E−01
rs6010790.86 (0.69–1.06)1.61E−10.90 (0.79–1.02)1.03E−10.89 (0.80–0.99)3.56E−26.65E−01
rs6802440.87 (0.70–1.08)2.08E−10.90 (0.79–1.01)8.68E−20.89 (0.80–0.99)3.66E−28.03E−01
rs6371370.91 (0.71–1.15)4.31E−10.74 (0.64–0.86)1.03E−40.78 (0.69–0.88)1.64E−41.76E−01
rs9512661.45 (1.01–2.06)4.15E−21.39 (1.22–1.57)9.83E−71.39 (1.23–1.57)1.25E−78.29E−01
rs5550180.79 (0.63–0.99)4.50E−20.91 (0.80–1.02)1.22E−10.88 (0.79–0.98)2.43E−23.30E−01
rs6470410.80 (0.64–1.01)6.74E−20.91 (0.80–1.02)1.27E−10.89 (0.79–0.98)3.15E−24.04E−01
rs169699682.04 (1.15–3.62)1.47E−21.40 (1.23–1.59)4.14E−71.42 (1.25–1.61)4.49E−82.37E−01
rs6606520.80 (0.63–1.00)5.85E−20.95 (0.83–1.08)4.49E−10.92 (0.82–1.02)1.37E−12.27E−01
rs5787761.01 (0.80–1.26)9.58E−10.72 (0.62–0.82)3.21E−60.79 (0.70–0.88)7.09E−51.26E−02
rs64953070.86 (0.69–1.08)2.06E−10.91 (0.81–1.03)1.62E−10.90 (0.81–1.00)7.22E−26.86E−01
rs10517301.38 (0.98–1.95)6.76E−21.40 (1.23–1.59)5.88E−71.39 (1.23–1.57)1.16E−79.39E−01
rs37430781.05 (0.84–1.30)6.82E−10.76 (0.65–0.87)2.68E−40.84 (0.74–0.94)4.48E−31.82E−02
rs37430770.80 (0.59–1.06)1.28E−10.91 (0.80–1.02)1.20E−10.89 (0.79–0.99)3.97E−23.42E−01
rs13172861.27 (0.98–1.63)6.56E−21.36 (1.19–1.54)4.44E−61.33 (1.19–1.49)1.10E−65.91E−01
rs9386820.90 (0.71–1.15)4.07E−10.76 (0.65–0.87)2.87E−40.79 (0.70–0.89)3.20E−42.59E−01
rs116376300.91 (0.71–1.15)4.22E−10.75 (0.65–0.87)2.10E−40.79 (0.70–0.89)2.90E−42.12E−01
GSC3_260.73 (0.29–1.84)5.07E−10.77 (0.59–0.99)4.69E−20.76 (0.59–0.97)3.17E−27.94E−01
rs71775140.97 (0.76–1.23)7.87E−10.76 (0.65–0.88)3.10E−40.81 (0.71–0.92)1.21E−39.29E−02
rs64953080.98 (0.77–1.25)8.82E−10.76 (0.65–0.87)2.64E−40.81 (0.71–0.92)1.34E−37.01E−02
rs80420591.00 (0.78–1.28)9.94E−10.76 (0.65–0.88)3.23E−40.82 (0.72–0.92)2.01E−35.70E−02
rs80423741.01 (0.79–1.29)9.15E−10.77 (0.66–0.89)5.21E−40.83 (0.73–0.93)3.33E−35.55E−02
rs48870691.01 (0.79–1.29)9.31E−10.76 (0.65–0.87)2.40E−40.82 (0.72–0.92)1.83E−34.36E−02
rs81924750.74 (0.23–2.35)6.08E−10.77 (0.58–1.02)6.80E−20.76 (0.58–0.99)4.77E−27.68E−01
rs64953090.94 (0.72–1.21)6.13E−10.75 (0.64–0.87)2.67E−40.79 (0.70–0.90)5.41E−41.67E−01
rs129140080.53 (0.13–2.12)3.67E−10.73 (0.54–0.97)3.53E−20.71 (0.53–0.95)2.21E−25.39E−01
rs174872231.59 (1.07–2.36)2.07E−21.35 (1.19–1.54)3.92E−61.37 (1.21–1.54)3.58E−74.66E−01
rs19963711.10 (0.72–1.69)6.55E−11.15 (1.01–1.30)3.46E−21.14 (1.01–1.28)3.95E−26.81E−01
  • NOTE: Values in boldface denote SNPs discussed in the text. ORs are for each copy of the nonreference allele.