Table 3.

Results for novel, sequencing-discovered genetic variants in the CHRNA5-CHRNA3 intergenic region

Novel variantRs number (if available)Position (bp)Minor alleleMajor alleleCOGEND European-American original (N = 1,591)
MAFPOR (95% CI)Maximum r2 with previously genotyped SNPs
GSC3_276671157TAAGDEL0.01000.67731.16 (0.57–2.36)<0.2
GSC3_476671923AT0.00280.3510.51 (0.13–2.09)0.46
GSC3_15rs6201032776679839AG0.36660.84741.02 (0.87–1.18)0.94
GSC3_1676679938DELTACTC0.04930.037260.71 (0.51–0.98)0.95
GSC3_17rs5595882076681412TG0.00980.17221.70 (0.79–3.61)<0.2
GSC3_18rs5770895376683263TC0.00390.60570.74 (0.23–2.36)0.35
GSC3_2076684921TDEL0.37190.90451.01 (0.87–1.17)0.97
GSC3_2676693692GA0.06480.0063860.67 (0.50–0.89)0.25
GSC3_2776694121TG0.00600.70981.19 (0.48–2.97)<0.2
GSC3_2876695823TC0.00630.65320.81 (0.33–2.00)<0.2
GSC3_2976696413GC0.00280.35210.51 (0.13–2.09)0.46
  • NOTE: Logistic regression, additive model.