Table 2.

Association of the best single SNP in each gene to CMT risk

Gene	Best P_raw data set 1	Best P_raw data set 2	Best P_raw total	Best P_Bonf total	Odds ratio total	F_cases/F_controls total
BRCA2	0.0032	6.7 × 10⁻⁴	3.9 × 10⁻⁶	1.4 × 10⁻⁴	4.24	0.97:0.88
BRCA1	0.012	0.18	1.3 × 10⁻⁴	0.0049	3.74	0.97:0.91
FGFR2	0.018	0.11	0.0047	0.18	1.88	0.90:0.83
TOX3	0.29	0.023	0.014	0.52	1.80	0.92:0.86
CHEK2	0.37	0.015	0.034	1.0	1.40	0.57:0.49
MAP3K1	0.025	0.54	0.042	1.0	1.43	0.79:0.72
LSP1	0.036	0.64	0.11	1.0	1.45	0.89:0.85
RCAS1	0.25	0.063	0.16	1.0	1.42	0.91:0.88
TP53	0.010	0.80	0.20	1.0	1.23	0.38:0.33
ERBB2	0.30	0.33	0.24	1.0	1.45	0.95:0.93
N_cases	89	122	212	212	212	212
N_controls	85	59	143	143	143	143

Abbreviations: P_raw, the best χ² single SNP P value obtained for each gene [nominal association (P_raw < 0.05) is indicated in bold]; P_Bonf, Bonferroni corrected P values [significant association (P_Bonf < 0.05) is indicated in bold]; F_cases/F_controls, the risk allele frequency in cases and controls.