Table 1.

Summary of significantly differentially expressed miRNAs in HCC compared with normal liver tissues

miRNAP *Fold change Chromosome location
Decreased expression
miR-29c0.0070.1741q32.2
miR-99a0.0240.21921q21.1
miR-1000.0220.20911q24.1
miR-1010.0090.2141p31.3
9p24.1
miR-125b0.0100.15311q24.1
21q21.1
miR-1950.0150.20217p13.1
miR-199a-5p0.0140.1491q24.3
19p13.2
miR-199b-3p0.0090.1129q34.11
miR-2150.0180.0931q41
miR-2230.0290.267Xq12
miR-3650.0070.12716p13.12
miR-3780.0020.1395q33.1
miR-422a0.0050.16615q22.31
miR-4240.0010.092Xq26.3
miR-520c-3p0.0360.21819q13.41
Increased expression
miR-18a0.0393.22313q31.3
miR-18b0.0164.077Xq26.2
miR-250.0453.2307q22.1
miR-930.0244.1117q22.1
miR-127-3p0.0146.77014q32.31
miR-2100.0403.78511p15.5
miR-216a0.0126.4282p16.1
miR-2220.0114.964Xp11.3
miR-224<0.00127.231Xq28
miR-362-5p0.0163.902Xp11.23
miR-3820.0205.66114q32.31
miR-491-5p0.0115.2229p21.3
miR-519b-5p0.0166.86519q13.41
miR-5270.0265.74519q13.41
  • * P values were calculated using Significance Analysis of Microarrays in the Bioconductor package (details in Materials and Methods). P value <0.05 was considered statistically significant.

  • Only those miRNAs whose expression levels displayed >0.5-fold decrease or 2-fold increase in HCC tissues were listed.