Table 1.

[11C]-Erlotinib biodistribution (% dose/g) 1 h post–i.v. injection in nude mice bearing lung cancer tumors

TissueA549, mean ± SE (n = 3)NCI358, mean ± SE (n = 3)HCC827, mean ± SE (n = 2)
Blood1.06 ± 0.240.56 ± 0.080.53 ± 0.03
Brain0.66 ± 0.220.29 ± 0.070.28 ± 0.02
Muscle0.72 ± 0.180.29 ± 0.070.28 ± 0.03
Lungs1.82 ± 0.460.80 ± 0.090.82 ± 0.02
Heart1.84 ± 0.700.62 ± 0.160.44 ± 0.02
Bone0.73 ± 0.200.33 ± 0.030.32 ± 0.03
Pancreas2.97 ± 1.671.73 ± 0.151.20 ± 0.20
Spleen2.06 ± 0.650.87 ± 0.180.73 ± 0.05
Kidney4.28 ± 1.031.98 ± 0.241.69 ± 0.04
Skin1.78 ± 0.400.68 ± 0.120.55 ± 0.04
Liver14.94 ± 3.7313.34 ± 2.5110.55 ± 1.47
Tumor1.62 ± 0.470.69 ± 0.113.66 ± 0.14