Table 5.

Risk of TGCT by DDE and PCB levels in the STEED study

All TGCTSeminomaNonseminoma
OR * (95% CI)OR * (95% CI)OR * (95% CI)
Low DDE (<147 ng/g lipid)
    Cases/controls (n)343/455123/455219/455
    Sum of PCBs Q11.001.001.00
    Sum of PCBs Q20.59 (0.41–0.85)0.70 (0.41–1.19)0.56 (0.37–0.85)
    Sum of PCBs Q30.67 (0.42–1.06)0.72 (0.37–1.41)0.62 (0.36–1.07)
    Sum of PCBs Q40.75 (0.40–1.41)1.05 (0.45–2.44)0.59 (0.27–1.28)
    Ptrend0.360.930.15
High DDE (≥147 μg/g lipid)
    Cases/controls (n)390/457189/457201/457
    Sum of PCBs Q11.001.001.00
    Sum of PCBs Q20.41 (0.20–0.85)0.33 (0.13–0.87)0.45 (0.20–1.00)
    Sum of PCBs Q30.27 (0.13–0.56)0.35 (0.14–0.91)0.21 (0.09–0.48)
    Sum of PCBs Q40.28 (0.13–0.60)0.27 (0.10–0.74)0.28 (0.12–0.66)
    Ptrend0.030.110.04
    Pinteraction0.480.290.72
  • * Adjusted for reference age, race, serum date, family history of TGCT, cryptorchism, age at serum draw, BMI, and height.