Table 1.

Characteristics of different regions defined by the proliferation, ER, and immune axes in Fig. 1

RegionDominant features
1Small tumors, tubular and lobular histology, grade 1 and 2, expression of basal like marker, ⇒ normal-like subtype
2Ductal and lobular histology, highest expression of ER, absence of immune-related transcripts, elderly patients, ⇒ luminal A subtype
3Ductal histology, ER positive and negative, presence and absence of ERBB2 amplification, variable expression of immune-related transcripts, ⇒ luminal B + ER negative but nonbasal-like + ERBB2 subtype
4Ductal and medullary histology, grade 2 and 3, ERBB2 negative, high expression of basal-like marker, younger patients, high expression of immune-related transcripts ⇒ basal-like A (advantageous prognosis)
5Ductal histology, grade 2 and 3, ERBB2 negative, high expression of basal-like marker, younger patients, low expression of immune-related transcripts ⇒ basal-like B (bad prognosis)
  • NOTE: ⇒ tumors within a region are assumed to relate to one or more intrinsic subtypes ( 3).